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Interactions Between Cocaine and Ethanol and Disulfiram - 1

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00094289
Recruitment Status : Unknown
Verified July 2005 by National Institute on Drug Abuse (NIDA).
Recruitment status was:  Active, not recruiting
First Posted : October 15, 2004
Last Update Posted : January 11, 2017
Information provided by:
National Institute on Drug Abuse (NIDA)

Brief Summary:
The purpose of this study is to assess potential interactions between intravenous cocaine and ethanol and oral disulfiram.

Condition or disease Intervention/treatment Phase
Alcohol-Related Disorders Cocaine-Related Disorders Drug: Disulfiram Phase 1

Detailed Description:
This is a two-site, double blind, placebo-controlled inpatient study to determine the cardiovascular and psychiatric safety of alcohol use in cocaine-dependent subjects who had used cocaine after treatment with disulfiram.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 16 participants
Primary Purpose: Treatment
Official Title: Interactions Between IV Cocaine and Ethanol and Oral Disulfiram
Study Start Date : August 2004
Study Completion Date : July 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Drug Reactions
Drug Information available for: Disulfiram

Primary Outcome Measures :
  1. Safety assessments
  2. Psychological effects

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Must meet DSM-4 criteria for cocaine abuse or dependence and are not seeking treatment.
  • Ability to verbalize understanding of consent form and provide written informed consent and verbalize willingness to complete study procedures; be able to comply with protocol requirements.

Exclusion Criteria:

  • Please contact site for more information.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00094289

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United States, California
UCLA Integrated Substance Abuse Program
Los Angeles, California, United States, 90024
United States, Texas
University of Texas Hlth Sci Ctr San Ant
San Antonio, Texas, United States, 78284 7828
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
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Principal Investigator: John Roache, Ph.D. University of Texas Health Sci Cntr, San Antonio
Layout table for additonal information Identifier: NCT00094289    
Other Study ID Numbers: NIDA-MDS-0003-1
First Posted: October 15, 2004    Key Record Dates
Last Update Posted: January 11, 2017
Last Verified: July 2005
Additional relevant MeSH terms:
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Cocaine-Related Disorders
Alcohol-Related Disorders
Pathologic Processes
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Alcohol Deterrents
Acetaldehyde Dehydrogenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action