Acute Renal Failure Trial Network (ATN) Study (ATN)
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ClinicalTrials.gov Identifier: NCT00076219 |
Recruitment Status :
Completed
First Posted : January 19, 2004
Results First Posted : August 16, 2013
Last Update Posted : August 23, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Acute Renal Failure | Procedure: renal replacement therapy | Phase 3 |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 1124 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | CSP #530 - Intensive vs. Conventional Renal Support in Acute Renal Failure |
Study Start Date : | October 2003 |
Actual Primary Completion Date : | September 2007 |
Actual Study Completion Date : | July 2008 |

Arm | Intervention/treatment |
---|---|
Experimental: Intensive renal replacement therapy
In the intensive management strategy, intermittent hemodialysis and sustained low-efficiency dialysis were provided 6 times per week, and continuous venovenous hemodiafiltration was provided at 35 mL/kg/hour.
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Procedure: renal replacement therapy
renal replacement therapy |
Active Comparator: Less-intensive renal replacement therapy
In the less-intensive management strategy, intermittent hemodialysis and sustained low-efficiency dialysis were provided 3 times per week, and continuous venovenous hemodiafiltration was provided at 20 mL/kg/hour.
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Procedure: renal replacement therapy
renal replacement therapy |
- 60-day All-cause Mortality [ Time Frame: 60 days ]60-day all-cause mortality

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Acute renal failure clinically consistent with a diagnosis of acute tubular necrosis
- Plan for renal replacement therapy by clinical team
- Receiving care in a critical care unit
- One non-renal organ failure or sepsis
- Age 18 or older
- Patient or surrogate provides informed consent
Exclusion Criteria:
- Baseline serum creatinine > 2 mg/dL (177 mol/L) in males, > 1.5 mg/dL (133 mol/L) in females
- Acute renal failure clinically believed to be due to an etiology other than acute tubular necrosis
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More than 72 hours since meeting both of the following conditions:
- Fulfillment of the definition of ARF; and
- BUN > 100 mg/dL (36 mmol/L)
- More than 1 hemodialysis treatment or more than 24 hours since starting continuous renal replacement therapy
- Prior kidney transplant
- Pregnancy
- Prisoner
- Weight > 128.5 kg
- Non-candidacy for renal replacement therapy
- Moribund state
- Patient not expected to survive 28 days because of underlying terminal chronic medical condition
- Comfort-measures-only status
- Participation in a concurrent interventional study
- Patient/surrogate refusal
- Physician refusal

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00076219

Study Chair: | Paul M. Palevsky | VA Pittsburgh Health Care System |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | US Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00076219 |
Other Study ID Numbers: |
530 |
First Posted: | January 19, 2004 Key Record Dates |
Results First Posted: | August 16, 2013 |
Last Update Posted: | August 23, 2013 |
Last Verified: | August 2013 |
Acute Renal Failure Renal Replacement Therapy multi-site randomization trial Hemodialysis |
Hemofiltration Critical Illness Hemodiafiltration |
Renal Insufficiency Acute Kidney Injury Kidney Diseases Urologic Diseases |