Genetic Registry for Rheumatoid Arthritis (NARAC)
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ClinicalTrials.gov Identifier: NCT00069472 |
Recruitment Status
:
Completed
First Posted
: September 29, 2003
Last Update Posted
: September 10, 2015
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Condition or disease |
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Rheumatoid Arthritis |
The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.
This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.
Study Type : | Observational |
Actual Enrollment : | 1062 participants |
Observational Model: | Family-Based |
Time Perspective: | Cross-Sectional |
Official Title: | Genetics of Rheumatoid Arthritis Registry |
Study Start Date : | October 2002 |
Actual Primary Completion Date : | August 2015 |
Actual Study Completion Date : | August 2015 |

- Genetic Association with risk for rheumatoid arthritis [ Time Frame: 10 years ]The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Adult onset RA
- Diagnosis of RA made between 18 and 60 years old
- Both parents alive and willing to participate
- Parents may have diagnosis of RA (affected) or be unaffected
Exclusion Criteria:
- Inflammatory bowel disease
- Lupus
- Psoriatic arthritis

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00069472
United States, New York | |
Feinstein Institute for Medical Research | |
Manhasset, New York, United States, 11030 |
Principal Investigator: | Peter K. Gregersen, MD | North Shore University Hospital |
Publications:
Responsible Party: | Peter Gregersen, Center Head, Robert S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Health System |
ClinicalTrials.gov Identifier: | NCT00069472 History of Changes |
Other Study ID Numbers: |
NIAMS-107 N01AR72232-001 ( U.S. NIH Grant/Contract ) |
First Posted: | September 29, 2003 Key Record Dates |
Last Update Posted: | September 10, 2015 |
Last Verified: | September 2015 |
Keywords provided by Peter Gregersen, North Shore Long Island Jewish Health System:
Genetics |
Additional relevant MeSH terms:
Arthritis Arthritis, Rheumatoid Joint Diseases Musculoskeletal Diseases |
Rheumatic Diseases Connective Tissue Diseases Autoimmune Diseases Immune System Diseases |