We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Therapy for Depressed Elders With Thought Problems

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00052091
Recruitment Status : Completed
First Posted : January 23, 2003
Last Update Posted : January 29, 2018
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Pat Arean, University of Washington

Brief Summary:
This study will compare the effectiveness of Problem Solving Therapy and Brief Supportive Therapy in treating elderly patients with major depression and thought problems.

Condition or disease Intervention/treatment Phase
Depression Cognition Disorders Behavioral: Problem Solving Therapy Behavioral: Brief Supportive Therapy Phase 3

Detailed Description:

Patients who suffer from a combination of major depression and executive dysfunction symptoms often respond poorly to treatment with antidepressants. It is important, therefore, to find effective alternative therapies to treat these symptoms.

Patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either PST or BST. Following treatment, patients are followed for 6 months to determine functional and clinical outcomes. Depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 221 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: PST in Geriatric Depression With Executive Dysfunction
Study Start Date : September 2002
Primary Completion Date : March 2008
Study Completion Date : March 2008

Arm Intervention/treatment
Experimental: 1 Problem Solving Therapy
12 weekly sessions of problem solving therapy (PST)
Behavioral: Problem Solving Therapy
A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.
Experimental: 2 Brief Supportive Therapy
12 weekly sessions of brief supportive therapy (BST)
Behavioral: Brief Supportive Therapy
A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.

Primary Outcome Measures :
  1. Hamilton Rating Scale for Depression [ Time Frame: Measured at screening, weeks 1 through 12, and week 36 ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Nonpsychotic, unipolar major depression
  • Cognitive impairment
  • English speaking

Exclusion Criteria:

  • High suicide risk
  • Dementia
  • Acute or severe medical illness
  • Current psychotherapy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00052091

United States, California
University of California at San Francisco
San Francisco, California, United States, 94143
United States, New York
Weill Medical College of Cornell University
White Plains, New York, United States, 10605
Sponsors and Collaborators
University of Washington
National Institute of Mental Health (NIMH)
Principal Investigator: Patricia A. Arean, PhD University of California at San Francisco

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Pat Arean, Professor, Psychiatry and Behavioral Sciences, University of Washington
ClinicalTrials.gov Identifier: NCT00052091     History of Changes
Other Study ID Numbers: H7472-19384-8
R01MH063982 ( U.S. NIH Grant/Contract )
First Posted: January 23, 2003    Key Record Dates
Last Update Posted: January 29, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes

Keywords provided by Pat Arean, University of Washington:

Additional relevant MeSH terms:
Depressive Disorder
Cognition Disorders
Behavioral Symptoms
Mood Disorders
Mental Disorders
Neurocognitive Disorders