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YM598 in Patients With Rising PSA After Initial Therapy for Localized Prostate Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00050297
Recruitment Status : Terminated
First Posted : December 4, 2002
Last Update Posted : June 7, 2012
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to determine the optimal dosage of YM598 for slowing down disease progression in patients with rising PSA after initial therapy for localized prostate cancer.

Condition or disease Intervention/treatment Phase
Prostate Cancer Drug: YM598 Phase 2

Study Design

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Completion Date : February 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Prostate Cancer
U.S. FDA Resources

Arms and Interventions

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00050297

University Clinic AZ
Brussels, Belgium
University Clinic UCL St. Luc
Brussels, Belgium
Czech Republic
Private Urology Out-patient Ward
Jablonec nad Nisou, Czech Republic
Clinic of Urology, University Hospital
Králové, Czech Republic
Clinic of Urology, University Hospital
Olomouc, Czech Republic
Clinic of Urology, University Hospital
Prague, Czech Republic
Hôpital Bichat, service de Urology
Paris, France
Haingasse 22
Bad Homburg, Germany, 61348
Klinik und Poliklinik für Urologie, Universitätsklinikum Carl-Gustav-Carus
Dresden, Germany
Klinik u. Poliklinik für Urologie, Philipps Universität, Baldingerstraße
Marburg, Germany
Krummbogen 15
Marburg, Germany
Regional Hospital, Department of Urology
Bydgoszcz, Poland
MedSource Poland
Gdansk, Poland
Bielanski Hospital, Department of Urology
Warszawa, Poland
Oncology Center, Department of Urinary Tract Cancer
Warszawa, Poland
Medical University, Clinic of Urology
Wroclaw, Poland
Complejo Hospitaliaro Juan Canalejo, Servicio de Urología
Corunna, Spain
Fundacion Hospital Alcorcón, Servicio Urología
Madrid, Spain
Hospital Universitario Principe de Asturias, Servicio de Urología, Ctra.
Madrid, Spain
United Kingdom
Department of Urology, Bristol Royal Infirmary
Bristol, United Kingdom
Department of Urology, Gartnavel Hospital
Glasgow, United Kingdom
Department of Urology, Norfolk & Norwich Hospital
Norwich, United Kingdom
Department of Urology, Taunton & Somerset Hospital
Taunton, United Kingdom
Sponsors and Collaborators
Astellas Pharma Inc
Astellas Pharma US, Inc.
More Information

ClinicalTrials.gov Identifier: NCT00050297     History of Changes
Other Study ID Numbers: 598-CL-004
First Posted: December 4, 2002    Key Record Dates
Last Update Posted: June 7, 2012
Last Verified: June 2012

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases
Endothelin Receptor Antagonists
Molecular Mechanisms of Pharmacological Action