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Mohawk Culture, Behavior, Toxicant Exposure and Health

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00043238
First Posted: August 8, 2002
Last Update Posted: April 14, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
This study will determine the pathways between Mohawk cultural identification and specific behaviors related to pollutant exposure, and determine the effects of these factors and the pollutant exposure on physiologically and socially significant outcomes.

Condition
Thyroid Diseases Cognition Disorders

Study Type: Observational
Official Title: Mohawk Culture, Behavior, Toxicant Exposure and Health

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 220
Study Completion Date: July 2005
Primary Completion Date: July 2005 (Final data collection date for primary outcome measure)
Detailed Description:
Considerable concern now exists over possible effects on human physical and psychological development of endocrine disrupting environmental contaminants such as polychlorinated biphenyls (PCBs). Native American communities are particularly at risk owing to subsistence systems and a cultural ethos involving greater contact with the physical environment. The proposed study follows-up 220 Mohawk adolescents aged 17-21 years, who participated in a previous study when they were 10-16 years old. All adolescents are members of the Mohawk Nation at Akwesasne which is located on the St. Lawrence River and is adjacent to hazardous waste sites where PCBs have contaminated the local ecology. The investigation examines the interrelationship between Mohawk cultural identity, traditional Mohawk customs, behaviors related to toxicant exposure and current toxicant burden. Serum level of PCBs will be assessed by congener specific analysis. The study will determine the relationship of congeners and their hydroxylated metabolites to thyroid function (levels of triiodothyronine, free triiodothyronine, thyroxine, free thyroxine, thyrotropin and anti-thyroid antibodies), and 2) psychosocial outcomes including school behavior and performance, hyperactivity, and adaptation to the community. Data gathered for the past study will be employed to assess variation in metabolism of PCBs, as well as how earlier measures of cognition and hyperactivity relate to 17 year old psychosocial outcomes. Variation in susceptibility to PCB effects will be determined by examining the effects of concurrent toxicant exposure (hexachlorobenzene, Mirex, dichlorodiphenyldichloroethene, lead), diet, and indicators of PCB metabolism, on the focal measures of adult functioning. The proposed study will clarify the causal pathways between culturally identifying behavior, PCB exposure and body burden, thyroid functioning, cognitive functioning, social behavior and school functioning while identifying activities that are important to maintain cultural identify and unrelated to exposure.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Participation in previous study of Mohawk adolescent well-being is required for participation in this project.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00043238


Locations
United States, New York
First Environments Research Project Office
Akwesasne, New York, United States, 13655
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00043238     History of Changes
Other Study ID Numbers: 10904-CP-001
First Submitted: August 7, 2002
First Posted: August 8, 2002
Last Update Posted: April 14, 2015
Last Verified: April 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
PCBs
Thyroid
Hyperactivity
School Performance
Mohawk Tribe

Additional relevant MeSH terms:
Thyroid Diseases
Cognition Disorders
Endocrine System Diseases
Neurocognitive Disorders
Mental Disorders