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Safety and Tolerability Study of Farnesyl Protein Transferase Inhibitor in Combination With Gemcitabine and Cisplatin in Advanced Cancer (Study P01499)(TERMINATED)

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ClinicalTrials.gov Identifier: NCT00040534
Recruitment Status : Terminated
First Posted : July 1, 2002
Last Update Posted : February 16, 2015
Sponsor:
Information provided by (Responsible Party):
Merck Sharp & Dohme Corp.

Brief Summary:

The purpose of this study is to determine the safety and tolerability of an oral Farnesyl Protein Transferase

Inhibitor (SCH 66336) when given in combination with Gemcitabine and Cisplatin in patients with advanced cancer.


Condition or disease Intervention/treatment Phase
Neoplasms Drug: Farnesyl Protein Transferase Inhibitor Phase 1

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : January 2001
Actual Primary Completion Date : July 2004
Actual Study Completion Date : July 2004




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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Advanced cancer for which there is no treatment available which would have a reasonable chance of disease palliation or cure
  • Age greater than or equal to 18.
  • SWOG performance Status less than or equal to 2.
  • Meets protocol requirements for specified laboratory values.
  • Written informed consent and cooperation of patient.

Exclusion Criteria:

  • Prior treatment with an FPTI
  • Knowledge of intracranial metastases or carcinomatous meningitis.
  • Poor medical risks because of nonmalignant systemic disease or uncontrolled active infection.
  • Medical conditions that would interfere with taking oral medications.
  • Significant uncontrolled diarrhea.
  • Chemotherapy, radiotherapy or major surgery within 4 weeks; full recovery from prior treatment.
  • Concomitant use of CYP3A inhibitors/inducers per protocol.
  • Known HIV positivity or AIDS-related illness.
  • Pregnant or nursing women.
  • Men or women of childbearing potential who are not using an effective method of contraception.
  • Concurrent chemotherapy, hormonal therapy, radiotherapy or immunotherapy.
  • QTc prolongation (>440 msecs) at baseline.
  • Patients with previous high-dose therapy requiring stem cell rescue or bone marrow transplant, or irradiation to >30% of bone marrow-containing areas.
  • Patients that have received Mitomycin-C or nitrosoureas.