Genetic Modifiers of Cystic Fibrosis: Sibling Study
|ClinicalTrials.gov Identifier: NCT00037778|
Recruitment Status : Completed
First Posted : May 21, 2002
Last Update Posted : August 31, 2016
|Condition or disease|
|Lung Diseases Cystic Fibrosis|
CF is a highly variable but inevitably fatal single gene disorder. Several lines of evidence suggest that genetic background contributes to the variability of cystic fibrosis phenotypes. The study will develop CF as a model for the identification of modifier genes by capitalizing on the availability of a large motivated population of affected twins and siblings.
The study is in response to a Request for Applications titled "Genetic Modifiers of Single Gene Defect Diseases" released in August 2000 and co-sponsored by the National Institute of Diabetes, Digestive, and Kidney Diseases.
The study has four aims: 1. To identify heritable CF phenotypes by twin study. Intrapair and interpair variance will be determined for selected CF phenotypes, and interclass correlations (monozygotic versus dizygotic) will be performed to identify CF phenotypes with a substantial heritable component. 2. To determine the contribution of genetic and other factors to the variability of CF phenotypes by analysis of affected sibs. Variance component methods will be used to evaluate the CF phenotypes that appear to be heritable based upon other studies or the results of aim 1. 3. To identify biologic phenotypes that correlate with heritable CF phenotypes by clinical study of twins and sibs. Multivariate analysis will be used to find biologic phenotypes associated with CF phenotypes. 4. To identify modifier genes and loci responsible for heritable CF phenotypes by linkage approaches. Identity by descent and transmission disequilibrium methods will be used to test linkage between candidate genes/loci and heritable CF phenotypes. To identify novel loci, genome-wide scans will be performed upon sib pairs selected for extreme concordance or discordance for heritable traits.
|Study Type :||Observational|
|Actual Enrollment :||3459 participants|
|Official Title:||Genetic Modifiers of Cystic Fibrosis: Sibling Study|
|Study Start Date :||September 2001|
|Actual Primary Completion Date :||February 2013|
|Actual Study Completion Date :||February 2013|
- Variation among genes in siblings with cystic fibrosis as assessed by DNA [ Time Frame: Single collection ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00037778
|United States, Maryland|
|Johns Hopkins University|
|Baltimore, Maryland, United States, 21287|
|Principal Investigator:||Garry Cutting||Johns Hopkins University|