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A Phase 1 Study of S-3304 in Patients With Solid Tumors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00033215
Recruitment Status : Unknown
Verified November 2003 by Shionogi.
Recruitment status was:  Active, not recruiting
First Posted : April 10, 2002
Last Update Posted : June 24, 2005
Information provided by:

Brief Summary:
To determine the maximum tolerated dose and safety profile of S-3304 in patients with biopsy accessible cancer who have failed previous therapy or to whom no standard therapies are available. To determine the pharmacokinetic profile of S-3304 in this patient population

Condition or disease Intervention/treatment Phase
Solid Tumors Drug: S-3304 Phase 1

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 28 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 1 Study of S-3304 in Patients With Solid Tumors
Study Start Date : November 2001
Estimated Study Completion Date : October 2003

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  • Biopsy proven diagnosis of solid tumor(s) with biopsy accessible lesion(s)
  • Must be able to tolerate oral medication Exclusion criteria
  • Patients with other serious illnesses
  • Patients who are receiving treatments

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00033215

United States, Colorado
University of Colorado Hospital
Denver, Colorado, United States, 80262
United States, Illinois
Rush-Presbyterian-St. Lukes Medical Center
Chicago, Illinois, United States, 60612
United States, New York
Roswell Park Cancer Center
Buffalo, New York, United States, 14263
United States, Ohio
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Sponsors and Collaborators
Shionogi Identifier: NCT00033215     History of Changes
Other Study ID Numbers: 0110P1416
First Posted: April 10, 2002    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: November 2003

Keywords provided by Shionogi:
matrix metalloproteinases
type IV collagenases

Additional relevant MeSH terms:
S 3304
Matrix Metalloproteinase Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action