Effects of Arousal and Stress in Anxiety
This study has several parts. One part will examine the influence of factors such as personality and past experience on reactions to unpleasant stimuli. Others will examine the effect of personality and emotional and attentional states on learning and memory.
When confronted with fearful or unpleasant events, people can develop fear of specific cues that were associated with these events as well as to the environmental context in which the events occurred via a process called classical conditioning. Classical conditioning has been used to model anxiety disorders, but the relationship between stress and anxiety and conditioned responses remains unclear. This study will examine the relationship between cued conditioning and context conditioning . This study will also explore the acquisition and retention of different types of motor, emotional, and cognitive associative processes during various tasks that range from mildly arousing to stressful.
|Official Title:||Effects of Arousal and Stress on Classical Conditioning|
|Study Start Date:||June 2001|
Objective: Fear and anxiety are adaptive responses to different types of threats. Fear is a short-duration response evoked by explicit threat cues. Fear can best be studied using Pavlovian fear conditioning. Studies 1 and 2 examine learning processes underlying fear conditioning as well as the influence of cognitive and affective processes on these learning processes. Anxiety is a more sustained state of apprehension evoked by unpredictable threat. Study 2 examines the interactions between anxiety induced experimentally and cognitive processes. Specifically, we seek to 1) characterize the effect of anxiety on key cognitive processes including working memory, attention control, conflict, and learning and memory. 2) examine the extent to which performance of cognitive tasks distract from anxiety, and 3) how physical exertion influences anxiety and its effects on cognition. Study 3 examines the effects of memory
retrieval on extinction.
Study population: This minimal-risk protocol will test medically and psychiatrically healthy volunteers aged 18-50. Pregnant or nursing women will be excluded.
Method: Fear and anxiety will be measured using the startle reflex to brief and loud sounds. Fear conditioning will be assessed using shock as unconditioned stimulus. Cognitive performance will be examined during periods of unpredictable shock anticipation or prior to giving a speech.
Outcome measures: The study will include cognitive performance and measure of aversive states, primarily the startle reflex.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00026559
|Contact: Christian Grillon, Ph.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Christian Grillon, Ph.D.||National Institute of Mental Health (NIMH)|