Prevalence of Sleep-Disordered Breathing in Children

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00022789
Recruitment Status : Completed
First Posted : August 14, 2001
Last Update Posted : March 13, 2014
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Edward Bixler, Milton S. Hershey Medical Center

Brief Summary:
To investigate the prevalence and clinical significance of sleep-disordered breathing (SDB) in children.

Condition or disease
Lung Diseases Sleep Apnea Syndromes

Detailed Description:


SDB in children appears to be a common condition, affecting approximately 1 to 3 percent of children. Many aspects of childhood SDB remain understudied and poorly understood, including its precise prevalence, the optimal means of identifying children who should undergo polysomnography, and the potentially major impact of this condition on health, cognitive development, and behavior.


The population-based, cross-sectional study of 6- to 16-year-old schoolchildren in Dauphin County, Pennsylvania is a two-part study. In the first part of the study, parents of every child enrolled in local elementary schools will complete a questionnaire that will assess general sleep, behavior, and learning problems. In the second part of the study, 1,000 children will be randomly selected based on their risk for SDB, as determined by the questionnaire. They will be evaluated in a sleep laboratory to determine the presence of SDB. A thorough pediatric ear, nose, throat, and pulmonary evaluation will be conducted; school records and behavior will also be assessed. The parents of the children will be interviewed, and information will be collected on the family history of risk factors associated with childhood SDB. This strategy will be beneficial in establishing the prevalence and clinical significance of SDB in children.

Study Type : Observational
Actual Enrollment : 700 participants
Observational Model: Cohort
Official Title: Prevalence of Sleep Disordered Breathing in Children
Study Start Date : August 2001
Actual Primary Completion Date : June 2006
Actual Study Completion Date : November 2006

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Ages Eligible for Study:   5 Years to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Random representative population sample of children in elementary school (K-5)

Inclusion Criteria:

  • Phase I: Sampled all children by questionnaire completed by parent or guardian in three school districts in Dauphin County, Pennsylvania
  • Phase II: Recruited a representative sample of 700 to complete a more detailed analysis in the laboratory

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00022789

United States, Pennsylvania
Pennsylvania State University Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Sponsors and Collaborators
Milton S. Hershey Medical Center
National Heart, Lung, and Blood Institute (NHLBI)
Study Chair: Edward O. Bixler, PhD Milton S. Hershey Medical Center

Responsible Party: Edward Bixler, Professor, Vice Chair Research, Milton S. Hershey Medical Center Identifier: NCT00022789     History of Changes
Other Study ID Numbers: 980
R01HL063772 ( U.S. NIH Grant/Contract )
First Posted: August 14, 2001    Key Record Dates
Last Update Posted: March 13, 2014
Last Verified: March 2014

Keywords provided by Edward Bixler, Milton S. Hershey Medical Center:
Sleep-Disordered Breathing

Additional relevant MeSH terms:
Lung Diseases
Respiratory Aspiration
Sleep Apnea Syndromes
Respiratory Tract Diseases
Respiration Disorders
Pathologic Processes
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases