Regulation of Sterol Homeostasis

This study has been completed.
Information provided by:
VA Office of Research and Development Identifier:
First received: July 3, 2001
Last updated: January 20, 2009
Last verified: December 2004

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Regulation of Sterol Homeostasis

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Study Start Date: April 1996
Estimated Study Completion Date: December 2000

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Hypertriglyceridemia and normal controls with normal lipids
  Contacts and Locations
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Please refer to this study by its identifier: NCT00018720

United States, Minnesota
VA Medical Center
Minneapolis, Minnesota, United States, 55417
Sponsors and Collaborators
VA Office of Research and Development
Investigator: Norman Javitt, M.D.
Investigator: Alan Hofmann, M.D.
Investigator: Loren Zech, M.D.
  More Information

No publications provided Identifier: NCT00018720     History of Changes
Other Study ID Numbers: GAST-026-95F
Study First Received: July 3, 2001
Last Updated: January 20, 2009
Health Authority: United States: Federal Government

Keywords provided by VA Office of Research and Development:
bile acids

Additional relevant MeSH terms:
Lipid Metabolism Disorders
Metabolic Diseases processed this record on November 25, 2015