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Protection Against Benzene Toxicity

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ClinicalTrials.gov Identifier: NCT00011453
Recruitment Status : Completed
First Posted : February 23, 2001
Last Update Posted : June 24, 2005
Information provided by:

Study Description
Brief Summary:
We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Condition or disease
Leukemia Aplastic Anemia

Study Design

Study Type : Observational
Primary Purpose: Screening
Time Perspective: Prospective
Official Title: NQO1 in Protection Against Benzene Toxicity
Study Start Date : July 1998
Estimated Study Completion Date : June 2001

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.
Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00011453

United States, Colorado
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80262
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
More Information

ClinicalTrials.gov Identifier: NCT00011453     History of Changes
Other Study ID Numbers: 9554-CP-001
First Posted: February 23, 2001    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: July 2002

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Aplastic anemia

Additional relevant MeSH terms:
Anemia, Aplastic
Hematologic Diseases
Bone Marrow Diseases