Mortality Follow-Up and Analyses of Men in the MRFIT
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|ClinicalTrials.gov Identifier: NCT00011206|
Recruitment Status : Completed
First Posted : February 13, 2001
Last Update Posted : March 17, 2014
|Condition or disease|
|Cardiovascular Diseases Heart Diseases Coronary Disease Myocardial Ischemia Diabetes Mellitus Cerebrovascular Accident Myocardial Infarction|
MRFIT was initiated in 1972 as a randomized, multicenter primary prevention trial designed to determine whether a special intervention consisting of smoking cessation, cholesterol reduction and control of high blood pressure, would result in a significant reduction in coronary heart disease (CHD) mortality, compared to usual care. Follow-up and analysis has continued on the 361,662 men screened and the 12,866 men randomized.
The National Death Index (NDI) will be used for continued follow-up of the MRFIT cohorts. An additional assay to establish IGF-1 and IGF binding protein will be added to the data set as a potential prognostic factor. The effort will focus on three primary aims related to long-term mortality. Aim 1 will relate nutritional-dietary data to twenty-five year mortality from coronary heart disease (CHD), stroke, cardiovascular disease (CVD), colon cancer, prostate cancer, and all causes for the 12,866 men randomized. Aim 2 will relate age, ethnicity, socioeconomic position, geographic location, major risk factors, low risk status, prior diabetes, and prior myocardial infarction to twenty-five year mortality for the 361,662 men screened. Aim 3 will relate insulin-like growth factor 1 (IGF-1), IGF binding protein, and fasting and one-hour glucose measurements from frozen baseline sera to mortality for the 12,866 men randomized.
|Study Type :||Observational|
|Study Start Date :||January 2001|
|Actual Primary Completion Date :||June 2006|
|Actual Study Completion Date :||June 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00011206
|Principal Investigator:||James Neaton||University of Minnesota, MN|