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Children's Activity and Nutrition III

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Augusta University Identifier:
First received: December 7, 2000
Last updated: December 21, 2015
Last verified: January 2005
To track blood pressure from childhood through adolescence.

Cardiovascular Diseases Hypertension Coronary Disease

Study Type: Observational

Further study details as provided by Augusta University:

Study Start Date: April 1992
Estimated Study Completion Date: April 2002
Detailed Description:


Children's Activity and Nutrition III was originally part of the Institute-initiated Studies of Children's Activity and Nutrition (SCAN), first funded in 1985. Children's Activity and Nutrition III was renewed in 1992 as a stand-alone project with a focus on assessment of the development of hemodynamic mechanisms responsible for blood pressure (BP) control within the context of ethnicity and family history of early myocardial infarction (MI), defined as having a parent or grandparent with an MI at less than 55 years of age and a family history.

Blacks have a higher mortality rate through middle adulthood than whites from coronary heart disease (CHD), the leading causes of death in the United States. Blacks have been found to exhibit greater cardiovascular (CV) response to stress (i.e., reactivity), a potential risk factor for CHD, as have individuals with a family history. . Although CHD has its pathobiologic origins in childhood, little longitudinal reactivity research has been conducted in youth, especially from childhood through late adolescence.


The study followed a multiethnic sample of 250 13 to 14 year olds for an additional 5 years to determine: 1) whether blood pressure (BP) reactivity during childhood predicted changes in resting BP, left ventricular mass and concentric remodeling, carotid artery wall elasticity and endothelial dependent arterial dilation up to 11 years later after controlling for other expected predictors (i.e., age, gender, ethnicity, resting BP, adiposity, ambulatory BP); 2) the influence of ethnicity, family history and a select group of moderator variables (i.e., environmental stress, anger and John Henryism coping styles, aerobic fitness on youth's cardiovascular (CV) reactivity; and 3) the stability of CV reactivity and a 24- hour ambulatory BP from childhood through late adolescence. The long- term objectives were to provide a better understanding of the development of CV reactivity in youth and its influence upon early pathobiologic markers of coronary heart disease prior to overt manifestation of disease.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria
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Please refer to this study by its identifier: NCT00007111

Sponsors and Collaborators
Augusta University
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Frank Treiber Augusta University
  More Information

Publications: Identifier: NCT00007111     History of Changes
Other Study ID Numbers: 956
R01HL035073 ( U.S. NIH Grant/Contract )
Study First Received: December 7, 2000
Last Updated: December 21, 2015

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Heart Diseases
Vascular Diseases
Arterial Occlusive Diseases processed this record on August 17, 2017