Children's Activity and Nutrition III

This study has been completed.
Sponsor:
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Georgia Regents University
ClinicalTrials.gov Identifier:
NCT00007111
First received: December 7, 2000
Last updated: December 21, 2015
Last verified: January 2005
  Purpose
To track blood pressure from childhood through adolescence.

Condition
Cardiovascular Diseases
Hypertension
Coronary Disease

Study Type: Observational

Further study details as provided by Georgia Regents University:

Study Start Date: April 1992
Estimated Study Completion Date: April 2002
Detailed Description:

BACKGROUND:

Children's Activity and Nutrition III was originally part of the Institute-initiated Studies of Children's Activity and Nutrition (SCAN), first funded in 1985. Children's Activity and Nutrition III was renewed in 1992 as a stand-alone project with a focus on assessment of the development of hemodynamic mechanisms responsible for blood pressure (BP) control within the context of ethnicity and family history of early myocardial infarction (MI), defined as having a parent or grandparent with an MI at less than 55 years of age and a family history.

Blacks have a higher mortality rate through middle adulthood than whites from coronary heart disease (CHD), the leading causes of death in the United States. Blacks have been found to exhibit greater cardiovascular (CV) response to stress (i.e., reactivity), a potential risk factor for CHD, as have individuals with a family history. . Although CHD has its pathobiologic origins in childhood, little longitudinal reactivity research has been conducted in youth, especially from childhood through late adolescence.

DESIGN NARRATIVE:

The study followed a multiethnic sample of 250 13 to 14 year olds for an additional 5 years to determine: 1) whether blood pressure (BP) reactivity during childhood predicted changes in resting BP, left ventricular mass and concentric remodeling, carotid artery wall elasticity and endothelial dependent arterial dilation up to 11 years later after controlling for other expected predictors (i.e., age, gender, ethnicity, resting BP, adiposity, ambulatory BP); 2) the influence of ethnicity, family history and a select group of moderator variables (i.e., environmental stress, anger and John Henryism coping styles, aerobic fitness on youth's cardiovascular (CV) reactivity; and 3) the stability of CV reactivity and a 24- hour ambulatory BP from childhood through late adolescence. The long- term objectives were to provide a better understanding of the development of CV reactivity in youth and its influence upon early pathobiologic markers of coronary heart disease prior to overt manifestation of disease.

  Eligibility

Ages Eligible for Study:   up to 100 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
No eligibility criteria
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00007111

Sponsors and Collaborators
Georgia Regents University
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Investigator: Frank Treiber Georgia Regents University
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00007111     History of Changes
Other Study ID Numbers: 956  R01HL035073 
Study First Received: December 7, 2000
Last Updated: December 21, 2015
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Arterial Occlusive Diseases
Arteriosclerosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases

ClinicalTrials.gov processed this record on February 07, 2016