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Study of Topical Calcitriol in Children With Psoriasis

This study has been completed.
Boston University
Information provided by:
Office of Rare Diseases (ORD) Identifier:
First received: September 11, 2000
Last updated: June 23, 2005
Last verified: September 2000


I. Determine the therapeutic efficacy and safety of topical calcitriol in children with psoriasis.

Condition Intervention
Psoriasis Drug: calcitriol

Study Type: Interventional
Study Design: Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 20
Study Start Date: July 2000
Estimated Study Completion Date: July 2000
Detailed Description:

PROTOCOL OUTLINE: Patients apply topical calcitriol in petrolatum on a psoriatic lesion daily. Patients also apply petrolatum without calcitriol to another psoriatic lesion daily.

Patients have both lesions photographed prior to therapy, monthly during therapy, and at the completion of therapy. Lesions are assessed weekly for 1 month and then every 2 weeks while on study. Blood samples are collected every 1 to 2 months and urine samples are collected every 2 weeks while on study.


Ages Eligible for Study:   4 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


--Disease Characteristics--

Diagnosis of psoriasis At least 2 lesions with area at least 30-50 cm2

--Prior/Concurrent Therapy--

No other concurrent therapy for psoriasis No concurrent calcium supplements greater than 1,000 mg/day No concurrent prednisone or other drugs affecting serum or urine calcium levels

--Patient Characteristics--

Renal: No high blood or urinary calcium levels

Other: Not pregnant Negative pregnancy test Fertile patients must use effective contraception

  Contacts and Locations
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Please refer to this study by its identifier: NCT00006275

Sponsors and Collaborators
National Center for Research Resources (NCRR)
Boston University
Study Chair: Michael F. Holick Boston University
  More Information Identifier: NCT00006275     History of Changes
Other Study ID Numbers: 199/15372
Study First Received: September 11, 2000
Last Updated: June 23, 2005

Keywords provided by Office of Rare Diseases (ORD):
dermatologic disorders
rare disease

Additional relevant MeSH terms:
Skin Diseases, Papulosquamous
Skin Diseases
Calcium Channel Agonists
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Vasoconstrictor Agents
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on August 17, 2017