The Safety and Efficacy of an Investigational Drug in Delaying the Progression of Alzheimer's Disease
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Estimated Study Completion Date:||June 2005|
|Estimated Primary Completion Date:||June 2005 (Final data collection date for primary outcome measure)|
This is a placebo-controlled, parallel-groups, 12 month, double-blind study, followed by a 3-month, double-blind, randomized withdrawal period to evaluate the efficacy and safety of an investigational drug (currently approved for other indications) to slow the progression of symptoms of AD. Patients with probable AD according to NINCDS-ADRDA criteria who have a Mini Mental State Examination (MMSE) score between 13 and 26 inclusive will be eligible for participation in the study.
Patients on stable doses of marketed cholinesterase inhibitors approved for the treatment of AD (except for tacrine) for at least 3 months are eligible for study entry. Use of NSAIDs (except aspirin 81 mg per day) is not allowed during the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00006187
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|Principal Investigator:||Klaus Beck, MD, PhD||Merck Sharp & Dohme Corp.|