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Coronary Artery Calcium, Exercise Tests, and CHD Outcome

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
The Cooper Institute Identifier:
First received: May 25, 2000
Last updated: March 12, 2014
Last verified: March 2014
To investigate coronary artery calcium (CAC), detected by electron beam computed tomography (EBCT), as a predictor of coronary heart disease (CHD) mortality and morbidity, stroke, and all-cause mortality in a historical cohort epidemiological study.

Cardiovascular Diseases
Coronary Disease
Cerebrovascular Disorders
Heart Diseases
Cerebrovascular Accident

Study Type: Observational

Further study details as provided by The Cooper Institute:

Study Start Date: September 1999
Study Completion Date: August 2006
Primary Completion Date: August 2006 (Final data collection date for primary outcome measure)
Detailed Description:


Dramatic advances in medical and interventional treatment of clinically overt CHD have contributed substantially, perhaps predominately, to the decline over the past three decades in CHD mortality that has occurred despite relatively unchanged rates of myocardial infarction. By analogy, it is attractive to assume that substantial benefit could also be given to individuals with significant but asymptomatic coronary artery disease if only they could be accurately diagnosed. In this context, research to determine whether or not a non-invasive method like EBCT has sufficient independent predictive value for CHD events to play a useful role in this process has potentially considerable clinical and public health importance.


Follow-up of the 5,400 women and 12,600 men will be for an average of about 2.75 years with approximately 15,000 woman-years and 35,000 man-years of observations being available for analyses by June 30, 2000. An important strength of the study is the self-reported key health variables at baseline for all study participants. In addition, objective measures of blood pressure, total cholesterol, HDL- cholesterol, triglyceride, plasma glucose, resting and exercise electrocardiograms (ECG), maximal health rates, cardiorespiratory fitness, and other clinical and biochemical measurements are available for about half of the participants. CAC by EBCT has been associated with prevalent CHD and with incident CHD in recent small prospective studies. However, it is unclear whether CAC is predictive of MI or CHD deaths, because currently available studies had few individuals with evidence of hard CVD endpoints. The large cohort with CAC measurements provides the power to investigate an association between CAC and CHD morbidity, stroke, and all- cause mortality in terms of thresholds or dose-response effects. Exercise test results and measures of conventional CHD risk factors, including several health behaviors and biochemical markers, are available for about 50 percent of the participants. This will allow evaluation of the separate and independent predictive value of CAC and exercise test results and the combination of these two exposures in relation to study outcomes. Furthermore, CAC scores, exercise test results, and the presence of conventional risk factors will be used together to identify participants at the highest risk of developing CHD outcomes.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria
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Please refer to this study by its identifier: NCT00005562

Sponsors and Collaborators
The Cooper Institute
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Michael Lamonte Cooper Institute for Aerobics Research
  More Information

Publications: Identifier: NCT00005562     History of Changes
Other Study ID Numbers: 5108
R01HL062508 ( US NIH Grant/Contract Award Number )
Study First Received: May 25, 2000
Last Updated: March 12, 2014

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Cerebrovascular Disorders
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases processed this record on April 28, 2017