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Multi-Ethnic Study of Atherosclerosis (MESA)

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ClinicalTrials.gov Identifier: NCT00005487
Recruitment Status : Unknown
Verified April 2012 by National Heart, Lung, and Blood Institute (NHLBI).
Recruitment status was:  Active, not recruiting
First Posted : May 26, 2000
Last Update Posted : July 29, 2016
Sponsor:
Information provided by (Responsible Party):
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To conduct a prospective observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced signs and symptoms) that predict progression to clinically overt cardiovascular disease in a diverse and representative population-based sample of men and women aged 35-84. Specifically the study shall: determine characteristics related to progression of subclinical to clinical cardiovascular disease; identify factors related to newer measures of subclinical disease and examine relationship of new to established measures; and develop population-based methods, suitable for application in future screening and intervention studies, for identifying asymptomatic persons at highest risk of clinical events.

Condition or disease
Atherosclerosis Cardiovascular Diseases Heart Diseases Coronary Artery Disease Coronary Disease Stroke Myocardial Infarction Heart Failure Diabetes Mellitus, Type 2 Hypertension Diabetes Mellitus

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 6000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Multi-Ethnic Study of Atherosclerosis (MESA)
Study Start Date : January 1999
Estimated Primary Completion Date : August 2015
Actual Study Completion Date : June 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Atherosclerosis
U.S. FDA Resources





Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 84 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Participants were recruited from the MESA Study Field Centers.
Criteria
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005487


Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: David Bluemke Johns Hopkins University
Principal Investigator: Gregory Burke Wake Forest University Health Sciences
Principal Investigator: Aaron Folsom University of Minnesota - Clinical and Translational Science Institute
Principal Investigator: Richard Kronmal University of Washington
Principal Investigator: Kiang Liu Northwestern University
Principal Investigator: Daniel O'Leary New England Medical Center Hospitals
Principal Investigator: Steven Shea Columbia University
Principal Investigator: Moyses Szklo Johns Hopkins University
Principal Investigator: Russell Tracy University of Vermont
Principal Investigator: Matthew Budoff Los Angeles Biomedical Research Institute
Principal Investigator: Karol Watson University of California, Los Angeles

Additional Information:
Study Data/Documents: Individual Participant Data Set  This link exits the ClinicalTrials.gov site
Identifier: MESA
NHLBI provides controlled access to IPD through BioLINCC. Access requires registration, evidence of local IRB approval or certification of exemption from IRB review, and completion of a data use agreement.

Publications of Results:
Auchincloss AH, Diez Roux AV, Brown DG, Erdmann CA, Bertoni AG. Associations between insulin resistance and resources for physical activity and healthy foods: the Multi-Ethnic Study of Atherosclerosis. Epidemiology. (In press)
Han C, Kronmal R. Two-part models for analysis of Agatston scores with possible proportionality constraints. Communications in Statistics-Theory and Methods. 2006;35(1):99-111.
Ix JH, Katz R, Kestenbaum B, Fried L, Kramer H, Stehman-Breen C, Shlipak M. Association of Mild to Moderate Decrements in Kidney Function and Coronary Calcification in the Multi-Ethnic Study of Atherosclerosis (MESA). Journal of the American Society of Nephrology. (In press)

Other Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
McKeown NM, Dashti HS, Ma J, Haslam DE, Kiefte-de Jong JC, Smith CE, Tanaka T, Graff M, Lemaitre RN, Rybin D, Sonestedt E, Frazier-Wood AC, Mook-Kanamori DO, Li Y, Wang CA, Leermakers ETM, Mikkilä V, Young KL, Mukamal KJ, Cupples LA, Schulz CA, Chen TA, Li-Gao R, Huang T, Oddy WH, Raitakari O, Rice K, Meigs JB, Ericson U, Steffen LM, Rosendaal FR, Hofman A, Kähönen M, Psaty BM, Brunkwall L, Uitterlinden AG, Viikari J, Siscovick DS, Seppälä I, North KE, Mozaffarian D, Dupuis J, Orho-Melander M, Rich SS, de Mutsert R, Qi L, Pennell CE, Franco OH, Lehtimäki T, Herman MA. Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia. 2018 Feb;61(2):317-330. doi: 10.1007/s00125-017-4475-0. Epub 2017 Nov 2.
Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkilä V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renström F, North KE, McKeown NM, Feitosa MF, Kanoni S, Smith CE, Garcia ME, Tiainen AM, Sonestedt E, Manichaikul A, van Rooij FJ, Dimitriou M, Raitakari O, Pankow JS, Djoussé L, Province MA, Hu FB, Lai CQ, Keller MF, Perälä MM, Rotter JI, Hofman A, Graff M, Kähönen M, Mukamal K, Johansson I, Ordovas JM, Liu Y, Männistö S, Uitterlinden AG, Deloukas P, Seppälä I, Psaty BM, Cupples LA, Borecki IB, Franks PW, Arnett DK, Nalls MA, Eriksson JG, Orho-Melander M, Franco OH, Lehtimäki T, Dedoussis GV, Meigs JB, Siscovick DS. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Am J Clin Nutr. 2015 Nov;102(5):1266-78. doi: 10.3945/ajcn.114.101238. Epub 2015 Sep 9.
Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JM. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan;101(1):135-43. doi: 10.3945/ajcn.114.095026. Epub 2014 Nov 26.
Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkilä V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, McKeown NM, Mozaffarian D, Singleton A, Stirrups K, Viikari J, Ye Z, Bandinelli S, Barroso I, Deloukas P, Forouhi NG, Hofman A, Liu Y, Lyytikäinen LP, North KE, Dimitriou M, Hallmans G, Kähönen M, Langenberg C, Ordovas JM, Uitterlinden AG, Hu FB, Kalafati IP, Raitakari O, Franco OH, Johnson A, Emilsson V, Schrack JA, Semba RD, Siscovick DS, Arnett DK, Borecki IB, Franks PW, Kritchevsky SB, Lehtimäki T, Loos RJ, Orho-Melander M, Rotter JI, Wareham NJ, Witteman JC, Ferrucci L, Dedoussis G, Cupples LA, Nettleton JA. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013 Jun;97(6):1395-402. doi: 10.3945/ajcn.112.052183. Epub 2013 May 1.

Responsible Party: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00005487     History of Changes
Other Study ID Numbers: 5003
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: July 29, 2016
Last Verified: April 2012

Keywords provided by National Heart, Lung, and Blood Institute (NHLBI):
Coronary Arteriosclerosis
Cerebrovascular Accident
Heart Failure, Congestive
Diabetes Mellitus, Non-Insulin Dependent

Additional relevant MeSH terms:
Diabetes Mellitus
Heart Failure
Infarction
Cardiovascular Diseases
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Myocardial Infarction
Diabetes Mellitus, Type 2
Atherosclerosis
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Ischemia
Pathologic Processes
Necrosis
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases