Jackson Heart Study (JHS) of Cardiovascular Diseases in African Americans (JHS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005485
Recruitment Status : Unknown
Verified April 2016 by National Heart, Lung, and Blood Institute (NHLBI).
Recruitment status was:  Active, not recruiting
First Posted : May 26, 2000
Last Update Posted : April 28, 2016
National Institute on Minority Health and Health Disparities (NIMHD)
Information provided by (Responsible Party):
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American men and women. The cohort is an expansion of the Jackson, Mississippi site of the Atherosclerosis Risk in Communities (ARIC) study and is a partnership among two minority institutions (Jackson State University and Tougaloo College), one majority institution in Jackson, Mississippi (the University of Mississippi Medical Center), the National Institutes of Health (NIH) National Center on Minority Health and Health Disparities (NCMHD), and the National Heart, Lung, and Blood Institute (NHLBI).

Condition or disease
Cardiovascular Diseases Heart Diseases Atherosclerosis Coronary Disease Hypertension Cerebrovascular Disorders

Detailed Description:


Heart disease and stroke remain the first and third leading killers of all Americans, with a disproportionate share of the burden borne by African Americans. Cardiovascular and total mortality are known to be higher among African Americans than among white Americans, but reasons for these differences remain unknown. In addition, well-documented declines in CVD and coronary disease mortality in the past three decades have not been shared equally between blacks and whites. Age-adjusted death rates were identical in both groups in 1980, but by 1994 the rate among African Americans was 14% higher than in whites. The race difference in magnitude of coronary heart disease (CHD) mortality is greater in women than men and higher in middle age, such that CHD deaths tend to occur in blacks about 5 years earlier than in whites. Excess cerebrovascular disease incidence and mortality in blacks are even greater than the differences noted in CHD.

Cardiovascular mortality rates in Mississippi, which are approximately 25% higher than the United States average, are the highest in the United States for all race-sex groups. Age-adjusted CVD mortality for African American women in Mississippi was 75% higher than in white women in 1994. The mortality for African American men was 47% higher than in white men.

Prevalence of hypertension is nearly 40% greater in African Americans than in whites and its sequelae are more frequent and severe. Evidence of target organ damage such as renal failure and left ventricular hypertrophy is more common in black than white hypertensives at comparable levels of blood pressure. Many risk factors are also more common in blacks, including diabetes, high serum lipoprotein levels [Lp(a)], and obesity (in women). Other risk factors, such as elevated total cholesterol, reduced high-density lipoprotein (HDL)-cholesterol, and heavy cigarette smoking, are more common in whites.


The Jackson Heart Study (JHS) initial examination, which began in the fall of 2000, included men and women ages 35 to 84, and took 3 years to complete. The coordinating center, located at Jackson State University, collects and analyzes data. The undergraduate training center at Tougaloo College offers coursework to students in public health and epidemiology, and provides practical experience in health research to prepare them for potential careers in these fields. The exam center at the University of Mississippi is responsible for recruiting participants and conducting examinations. JHS is uniquely positioned to answer key questions regarding the excess burden of CVD among African Americans and to address the critical shortage of minority investigators trained in epidemiology and prevention. These questions will be answered by incorporating state-of-the-art physiologic and epidemiologic methods in a stable population-based minority cohort, providing research experience, and building research capabilities at minority institutions. The Second Exam began in September 2005.

Study Type : Observational
Actual Enrollment : 5306 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Environmental and Genetic Factors That Influence Cardiovascular Disease in African Americans
Study Start Date : September 2000

Resource links provided by the National Library of Medicine

Biospecimen Retention:   Samples With DNA
Serum, plasma, urine, DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   35 Years to 84 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
African-American men and women residents of metropolitan Jackson, Mississippi

Inclusion Criteria:

  • African American
  • Residents of Jackson, Mississippi

Exclusion Criteria:

  • Institutionalization

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00005485

United States, Mississippi
Tougaloo College
Jackson, Mississippi, United States, 39174
University of Mississippi Medical Center Department of Medicine
Jackson, Mississippi, United States, 39213
Jackson State University
Jackson, Mississippi, United States, 39217
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Minority Health and Health Disparities (NIMHD)
Principal Investigator: Asoka Srinivasan, PhD Tougaloo College
Principal Investigator: Donna Antone-LaVigne, MPH, PhD Jackson State University
Principal Investigator: Marinelle Payton, MD, PhD Jackson State University
Study Director: Adolfo Correa, MD, PhD, MBA University of Mississippi Medical Center

Additional Information:

Responsible Party: National Heart, Lung, and Blood Institute (NHLBI) Identifier: NCT00005485     History of Changes
Other Study ID Numbers: 5001
268201300046C-4-0-1 ( U.S. NIH Grant/Contract )
268201300047C-4-0-1 ( U.S. NIH Grant/Contract )
268201300048C-4-0-1 ( U.S. NIH Grant/Contract )
268201300049C-4-0-1 ( Other Identifier: NHLBI )
268201300050C-4-0-1 ( Other Identifier: NHLBI )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: April 28, 2016
Last Verified: April 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Cerebrovascular Disorders
Arterial Occlusive Diseases
Vascular Diseases
Myocardial Ischemia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases