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The Jackson Heart Study of Cardiovascular Disease Among African Americans (JHS)

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ClinicalTrials.gov Identifier: NCT00005485
Recruitment Status : Active, not recruiting
First Posted : May 26, 2000
Last Update Posted : September 6, 2018
Sponsor:
Collaborator:
National Institute on Minority Health and Health Disparities (NIMHD)
Information provided by (Responsible Party):
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American men and women. The cohort is an expansion of the Jackson, Mississippi site of the Atherosclerosis Risk in Communities (ARIC) study and is a partnership among two minority institutions (Jackson State University and Tougaloo College), one majority institution in Jackson, Mississippi (the University of Mississippi Medical Center), the Mississippi State Department of Health, the National Institutes of Health (NIH) National Center on Minority Health and Health Disparities (NCMHD), and the National Heart, Lung, and Blood Institute (NHLBI).

Condition or disease
Cardiovascular Diseases Heart Diseases Atherosclerosis Coronary Disease Hypertension Cerebrovascular Disorders

Detailed Description:
The Jackson Heart Study (JHS) https://www.jacksonheartstudy.org/jhsinfo/, initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate- and graduate-level research training programs, and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents living in the Jackson, MS, metropolitan statistical area (MSA) of Hinds, Madison, and Rankin Counties. Participants were enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 31% (shared JHS/ARIC cohort); and secondary family members, 22%. Recruitment was limited to non-institutionalized adult African Americans 35-84 years old, except in a nested family cohort where those 21 to 34 years of age were also eligible. The final cohort of participants included 6.59% of all African American Jackson MSA residents aged 35-84 during the baseline exam (N-76,426, US Census 2000). Among these, approximately 3,700 gave consent that allows genetic research and deposition of data into dbGaP. Enrolled JHS participants received three back-to-back clinical examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) that have generated extensive longitudinal data on: traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other -omics investigations. Participants have been contacted annually to: update information; confirm vital statistics; document interim medical events, hospitalizations, and functional status; and obtain additional sociocultural information. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths. The JHS serves as a resource to the scientific community for novel research, promotes cardiovascular health in the local community, and encourages underrepresented minority students to pursue biomedical careers.

Study Type : Observational
Actual Enrollment : 5306 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Jackson Heart Study of Cardiovascular Disease Among African Americans
Actual Study Start Date : September 2000
Estimated Primary Completion Date : August 2024
Estimated Study Completion Date : August 2024

Resource links provided by the National Library of Medicine





Biospecimen Retention:   Samples With DNA
Serum, plasma, urine, DNA


Information from the National Library of Medicine

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Ages Eligible for Study:   35 Years to 84 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
African-American men and women residents of metropolitan Jackson, Mississippi
Criteria

Inclusion Criteria:

  • African American
  • Residents of Jackson, Mississippi

Exclusion Criteria:

  • Institutionalization

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005485


Locations
United States, Mississippi
Tougaloo College
Jackson, Mississippi, United States, 39174
University of Mississippi Medical Center Department of Medicine
Jackson, Mississippi, United States, 39213
Jackson State University
Jackson, Mississippi, United States, 39217
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Minority Health and Health Disparities (NIMHD)
Investigators
Principal Investigator: Wendy White, PhD Tougaloo College JHS UTEC
Principal Investigator: Marinelle Payton, MD, PhD Jackson State University JHS GTEC
Study Director: Adolfo Correa, MD, PhD, MBA University of Mississippi Medical Center JHS CC FC

Additional Information:
Publications:

Responsible Party: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00005485     History of Changes
Other Study ID Numbers: 5001
268201300046C-4-0-1 ( U.S. NIH Grant/Contract )
268201300047C-4-0-1 ( U.S. NIH Grant/Contract )
268201300048C-4-0-1 ( U.S. NIH Grant/Contract )
268201300049C-4-0-1 ( Other Identifier: NHLBI )
268201300050C-4-0-1 ( Other Identifier: NHLBI )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: September 6, 2018
Last Verified: August 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: The JHS adheres to NIH and NHLBI policies for data sharing of epidemiologic studies. Data from each cycle of an examination or follow-up component are prepared by the JHS Coordinating Center and sent to the NHLBI PO for distribution as a data set after the completion of each examination or two years after the baseline, follow-up, genetic, ancillary study, or other data set is finalized within the study for analysis for use in publication. De-identified data from Exams 1, 2 and 3 of the JHS are available and shared commonly through the JHS processes for presentation and publication, ancillary studies, and Vanguard Centers. Public datasets for Exam 1, Exam 2, and Exam 3 have been provided to BioLINCC and dbGaP.
Supporting Materials: Study Protocol
Informed Consent Form (ICF)
Time Frame: Data are currently available for exams 1, 2 and 3 and for hospitalizations for cardiovascular events (2000-2015+ for CHD and stroke; 2005-2015+ for heart failure) and mortality (2000-2017+). Data will be available indefinitely.
Access Criteria: Data can accessed from JHS with approved manuscript proposals and from dbGaP and BIOLINCC.
URL: https://www.jacksonheartstudy.org/

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Atherosclerosis
Coronary Disease
Coronary Artery Disease
Cerebrovascular Disorders
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Myocardial Ischemia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases