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Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: July 14, 2016
Last verified: November 2001
A detailed review was made of data pertinent to the occurrence of chronic Chagas disease in the United States.

Heart Diseases
Myocardial Diseases
Chagas Disease

Study Type: Observational

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: January 1993
Study Completion Date: December 1993
Detailed Description:


In Latin America, 16 to 18 million individuals are thought to have Chagas' disease and 90 million are considered to be at risk of infection. In the United States, the occurrence of Chagas' disease is virtually limited to individuals who have resided in Latin America where they acquired the infection, and then migrated to this country.


Data on the prevalence of positive serologic reactions for Trypanosoma cruzi (a protozoan causing Chagas cardiomyopathy) serve for calculating that a total of up to 74,000 Latin Americans residing in the United States have the chronic form of chagasic cardiomyopathy. The vast majority of these individuals are either undiagnosed, or misdiagnosed as having idiopathic dilated cardiomyopathy or coronary artery disease. Vector transmission of T. cruzi infection is very unlikely to occur in the United States because of variations in biological behavior of local species of insect vectors and because of changes in human living conditions. Transfusion of blood from infected but asymptomatic individuals is considered the most important mechanism of transmission of this disorder in the United States.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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No Contacts or Locations Provided
  More Information Identifier: NCT00005455     History of Changes
Other Study ID Numbers: 4488
Z01HL005264 ( US NIH Grant/Contract Award Number )
Study First Received: May 25, 2000
Last Updated: July 14, 2016

Additional relevant MeSH terms:
Heart Diseases
Chagas Disease
Cardiovascular Diseases
Euglenozoa Infections
Protozoan Infections
Parasitic Diseases processed this record on April 28, 2017