Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005455
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : July 15, 2016
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
A detailed review was made of data pertinent to the occurrence of chronic Chagas disease in the United States.

Condition or disease
Heart Diseases Myocardial Diseases Chagas Disease

Detailed Description:


In Latin America, 16 to 18 million individuals are thought to have Chagas' disease and 90 million are considered to be at risk of infection. In the United States, the occurrence of Chagas' disease is virtually limited to individuals who have resided in Latin America where they acquired the infection, and then migrated to this country.


Data on the prevalence of positive serologic reactions for Trypanosoma cruzi (a protozoan causing Chagas cardiomyopathy) serve for calculating that a total of up to 74,000 Latin Americans residing in the United States have the chronic form of chagasic cardiomyopathy. The vast majority of these individuals are either undiagnosed, or misdiagnosed as having idiopathic dilated cardiomyopathy or coronary artery disease. Vector transmission of T. cruzi infection is very unlikely to occur in the United States because of variations in biological behavior of local species of insect vectors and because of changes in human living conditions. Transfusion of blood from infected but asymptomatic individuals is considered the most important mechanism of transmission of this disorder in the United States.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Study Type : Observational
Study Start Date : January 1993
Actual Study Completion Date : December 1993

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria Identifier: NCT00005455     History of Changes
Other Study ID Numbers: 4488
Z01HL005264 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: July 15, 2016
Last Verified: November 2001

Additional relevant MeSH terms:
Heart Diseases
Chagas Disease
Cardiovascular Diseases
Euglenozoa Infections
Protozoan Infections
Parasitic Diseases