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Prospective Study of HIV Infection in Hemophiliacs

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00005309
First Posted: May 26, 2000
Last Update Posted: February 9, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Bloodworks (Puget Sound Blood Center)
  Purpose
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.

Condition
Acquired Immunodeficiency Syndrome HIV Infections Blood Disease Hemophilia A Hepatitis, Viral, Human Blood Transfusion Cytomegalovirus Infections

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by Bloodworks (Puget Sound Blood Center):

Study Start Date: July 1990
Estimated Study Completion Date: March 1995
Detailed Description:

BACKGROUND:

In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.

DESIGN NARRATIVE:

Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria
No eligibility criteria
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005309


Sponsors and Collaborators
Bloodworks (Puget Sound Blood Center)
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
OverallOfficial: George Gjerset Bloodworks (Puget Sound Blood Center)
  More Information

ClinicalTrials.gov Identifier: NCT00005309     History of Changes
Other Study ID Numbers: 3012
R01HL043512 ( U.S. NIH Grant/Contract )
First Submitted: May 25, 2000
First Posted: May 26, 2000
Last Update Posted: February 9, 2016
Last Verified: February 2016

Additional relevant MeSH terms:
Infection
Communicable Diseases
HIV Infections
Acquired Immunodeficiency Syndrome
Immunologic Deficiency Syndromes
Hemophilia A
Cytomegalovirus Infections
Hematologic Diseases
Hepatitis, Viral, Human
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immune System Diseases
Slow Virus Diseases
Blood Coagulation Disorders, Inherited
Blood Coagulation Disorders
Coagulation Protein Disorders
Hemorrhagic Disorders
Genetic Diseases, Inborn
Herpesviridae Infections
DNA Virus Infections
Hepatitis
Liver Diseases
Digestive System Diseases