Genetic and Environmental Determinants of Hypertension

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005149
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : January 21, 2016
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of Utah

Brief Summary:
To determine the pathophysiology of different types of essential hypertension by identifying the discrete effects of major genes and environmental variables as determinants of the subtypes of essential hypertension.

Condition or disease
Cardiovascular Diseases Heart Diseases Hypertension

Detailed Description:


Essential hypertension is believed to be a heterogeneous group of disorders, the subtypes of which could be related to sodium sensitivity, obesity, diabetes, calcium intake and metabolism, the renin-angiotensin balance, or membrane cation transport. Essential hypertension aggregates in families. The syndromes leading to hypertension may involve shared genes, shared environmental factors, or both.


In 1980 a series of biochemical and physiological tests were initiated in the 2,548 persons in 98 extended pedigrees in Utah. Most of the subjects were obtained from three major pedigree types: stroke cluster pedigrees; coronary heart disease cluster pedigrees; and pedigrees of Utah Hypertension Detection and Follow-up Program high blood pressure probands. Data were collected on personal history, medical family history and genealogy, anthropometrics, standard and 32-lead electro- cardiograms, multiple blood pressure measurements during sitting, standing, lying, tilting, isometric hand grip exercise, bicycle exercise, venipuncture and mental arithmetic. Cation tests included sodium-lithium countertransport, lithium-potassium co-transport, intracellular sodium, potassium, magnesium, sodium-potassium ATP-ase pump activity and binding sites and plasma levels of sodium, potassium, magnesium, ionized calcium and digoxin-like pump inhibitor. Information was also collected on stress, exercise, plasma renin activity, and urinary kallikrein. Statistical and pedigree analysis were conducted.

The same tests were also performed on 600 new population-based hypertensive subjects on drug therapy and again four months after interruption of drug therapy. Tests were conduced for specific subtypes of high blood pressure among the 600 subjects using individual variables and multivariate combinations of variables. Three hundred nuclear families were screened to test for familiality of subtype indicators and to identify those high blood pressure subtype indicator variables needing detailed pedigree analysis.

One thousand sequentially-sampled persons were studied for major genes, DNA probe linkage, and gene-environment interactions as determinants of specific types of hypertension.

Study Type : Observational
Study Start Date : February 1980
Study Completion Date : November 1992

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Williams RR, Hunt SC, Dadone MM, Hasstedt S, Smith JB, Ash KO, Kuida H: Preliminary Analysis of Sodium-Lithium Countertransport and Blood Pressure in Utah Pedigrees. In: Topics In Pathophysiology Of Hypertension (Villarreal H, Sambhi MP, Eds). Boston: Martinus Nijhoff Publishers. pp 112-135, 1984
Williams RR, Hunt SC, Dadone MM, Smith JB, Ash KO, Kuida K: Cation Flux and Other Possible Biological Markers of Genetically Predisposed Hypertension. In: Children's Blood Pressure, Report of the Eighty- Eighth Ross Conference on Pediatric Research (Filer LJ and Lauer RM, Eds). Columbus, Ohio: Ross Laboratories, pp 100-123, 1984 Identifier: NCT00005149     History of Changes
Other Study ID Numbers: 1020
R01HL024855 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: January 21, 2016
Last Verified: January 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Vascular Diseases