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Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00004781
First Posted: February 25, 2000
Last Update Posted: June 24, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Columbia University
Information provided by:
Office of Rare Diseases (ORD)
  Purpose

OBJECTIVES: I. Evaluate the development of oral manifestations of human immunodeficiency virus infection in relationship to the onset of immunologic alterations and systemic symptoms in different risk groups: gay/bisexual men, male intravenous drug users, and female intravenous drug users.

II. Evaluate the immune and inflammatory response to periodontal and other microbial pathogens.

III. Evaluate the bacterial species infecting the oral cavity in patients in these risk groups.


Condition
HIV Infections Candidiasis, Oral

Study Type: Observational
Study Design: Primary Purpose: Screening

Resource links provided by NLM:


Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment: 250
Study Start Date: September 1989
Detailed Description:

PROTOCOL OUTLINE:

Patients undergo a periodontal assessment every 6 months until medically unable to continue. The oral/dental exam includes saliva and gingival crevicular fluid analysis and, as indicated, oral photographs.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Human immunodeficiency virus infection (HIV) seropositive or seronegative At risk for HIV, i.e.: Gay/bisexual men Male intravenous drug users Female intravenous drug users No acquired immunodeficiency syndrome Currently enrolled in Columbia Presbyterian Medical Center protocol "The Natural History and Progression of HIV Infection"

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004781


Sponsors and Collaborators
National Institute of Dental and Craniofacial Research (NIDCR)
Columbia University
Investigators
Study Chair: Ira B. Lamster Columbia University
  More Information

ClinicalTrials.gov Identifier: NCT00004781     History of Changes
Other Study ID Numbers: 199/11861
CU-SDOS-5059
First Submitted: February 24, 2000
First Posted: February 25, 2000
Last Update Posted: June 24, 2005
Last Verified: February 1997

Keywords provided by Office of Rare Diseases (ORD):
HIV-associated candidiasis
candidiasis
disease-related problem/condition
fungal infection
immunologic disorders and infectious disorders
infection
rare disease

Additional relevant MeSH terms:
Infection
Communicable Diseases
HIV Infections
Candidiasis
Acquired Immunodeficiency Syndrome
Candidiasis, Oral
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Mycoses
Slow Virus Diseases
Mouth Diseases
Stomatognathic Diseases