Randomized Study of Intensive One-on-one Behavioral Treatment for Preschool Aged Children With Autism
OBJECTIVES: I. Determine the effectiveness of intensive one-on-one behavioral treatment in the home or neighborhood compared with at home, individualized, parent training in preschool aged children with autism.
II. Identify intake measures that predict differences in outcome between subjects in the experimental group.
|Autistic Disorder||Behavioral: intensive one-on-one behavioral treatment Behavioral: Individualized in home parent training|
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Randomized Study of Intensive One-on-one Behavioral Treatment Versus Individualized Parent Training in Preschool Aged Children With Autism|
- Wechsler Preschool and Primary Scales of Intelligence, 3rd ed. [ Time Frame: yearly for up to 4 years ]IQ
- Bayley Scales of Infant Development [ Time Frame: yearly for up to 4 years ]Alternate cognitive test administered to participants who did not achieve basal on WPPSI-III
- Merrill-Palmer Scale of Mental Tests [ Time Frame: yearly for up to 4 years ]Nonverbal cognitive skills
- Reynell Developmental Language Scales [ Time Frame: yearly for up to 4 years ]Language comprehension and expressive language
- Vineland Adaptive Behavior Scales - Survey Edition [ Time Frame: yearly for up to 4 years ]Parent interview on child's adaptive functioning
|Study Start Date:||May 1998|
|Study Completion Date:||April 2006|
|Primary Completion Date:||September 2004 (Final data collection date for primary outcome measure)|
Behavioral: intensive one-on-one behavioral treatment
PROTOCOL OUTLINE: This is a randomized study. Children are randomized to receive either 35 hours of intensive one-on-one behavioral treatment in the home and neighborhood for 2 years or individualized, in home parent training for 6 months.
A common group of tests to evaluate autism are administered at intake, 12 and 24 months into treatment, and when patients reach age 6.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004449
|Study Director:||Tristram Smith, Ph.D.||University of Rochester|