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Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

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ClinicalTrials.gov Identifier: NCT00004305
Recruitment Status : Completed
First Posted : October 19, 1999
Last Update Posted : June 24, 2005
Sponsor:
Collaborators:
Information provided by:

Study Description
Brief Summary:

OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N).

II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.


Condition or disease
IGA Glomerulonephritis

Detailed Description:

PROTOCOL OUTLINE:

Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.


Study Design

Study Type : Observational
Estimated Enrollment : 105 participants
Primary Purpose: Screening
Study Start Date : January 1998

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
  • IgA glomerulonephritis
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00004305


Locations
United States, Ohio
Ohio State University
Columbus, Ohio, United States
Sponsors and Collaborators
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ohio State University
Investigators
Study Chair: Lee A. Hebert Ohio State University
More Information

ClinicalTrials.gov Identifier: NCT00004305     History of Changes
Other Study ID Numbers: 199/11791
OSU-94H0338
First Posted: October 19, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: April 2002

Keywords provided by National Center for Research Resources (NCRR):
IgA glomerulonephritis
rare disease
renal and genitourinary disorders

Additional relevant MeSH terms:
Glomerulonephritis
Glomerulonephritis, IGA
Nephritis
Kidney Diseases
Urologic Diseases
Autoimmune Diseases
Immune System Diseases