Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug with surgery and/or radiation therapy may kill more tumor cells.
PURPOSE: This randomized phase III trial is studying surgery followed by different regimens of combination chemotherapy given together with radiation therapy and/or additional surgery to compare how well they work in treating patients with soft tissue sarcoma.
|Childhood Malignant Fibrous Histiocytoma of Bone Sarcoma||Biological: dactinomycin Drug: carboplatin Drug: cyclophosphamide Drug: epirubicin hydrochloride Drug: etoposide Drug: ifosfamide Drug: vincristine sulfate Procedure: adjuvant therapy Procedure: conventional surgery Procedure: neoadjuvant therapy Radiation: brachytherapy Radiation: radiation therapy||Phase 3|
|Study Design:||Allocation: Randomized
Primary Purpose: Treatment
|Official Title:||MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood|
|Study Start Date:||January 1995|
|Study Completion Date:||December 2009|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002898
|Institute of Child Health|
|Bristol, England, United Kingdom, BS2 8AE|
|Study Chair:||M. C. G. Stevens, MD||Institute of Child Health at University of Bristol|