The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
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|ClinicalTrials.gov Identifier: NCT00001603|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
The goal of this study is to learn how tumors of the upper airway and digestive passages (tongue, throat, mouth, and voicebox) affect the body's immune defenses and energy storage.
Previous studies have shown that tumors of the vocal tract produce signals that could help the tumor escape the body's immune defenses and use the body's energy and mineral stores to grow.
Researchers are hoping to learn more about what signals give tumor cells an advantage to live and grow, how tumor cells control these signals, and how these signals affect the rest of the body. This study will look closer at researchers belief that tumors in the vocal tract contain genes (genetic information) that abnormally function to allow the tumors to survive and grow against the attack of the body's normal immune system
Patients with cancerous tumors (squamous cell carcinoma) and benign (non-cancerous) tumors (papilloma) of the upper aerodigestive tract who are candidates for standard or investigational therapy are eligible to participate in this study.
Tumor cells will be collected from patients participating in the study, who will undergo standard surgical treatment or biopsies for their conditions. Once tumor cells are collected they can be analyzed for their genetic make-up.
In addition, patients will undergo several tests using skin, blood, and urine to look closely at the function of their immune systems and metabolism.
|Condition or disease|
|Esophageal Neoplasm Head and Neck Neoplasm Laryngeal Neoplasm Papilloma Squamous Cell Carcinoma|
|Study Type :||Observational|
|Estimated Enrollment :||93 participants|
|Official Title:||A Pilot Study of Immunoregulatory Factor Expression and Immune Responses in Patients With Squamous Cell Carcinoma or Papilloma of the Upper Aerodigestive Tract|
|Study Start Date :||December 1996|
|Estimated Study Completion Date :||December 2004|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001603
|United States, Maryland|
|National Institute on Deafness and Other Communication Disorders (NIDCD)|
|Bethesda, Maryland, United States, 20892|