A Study to Evaluate the Safety and Tolerability of Zidovudine (ZDV) in Premature Infants Born to HIV-Positive Women.
|ClinicalTrials.gov Identifier: NCT00000855|
Recruitment Status : Completed
First Posted : August 31, 2001
Last Update Posted : March 16, 2012
The purpose of this study is to examine the safety and tolerability of ZDV when given to premature infants born to HIV-positive women to prevent HIV infection.
ZDV has been used successfully to prevent the transmission of HIV from mother to child during pregnancy and birth. However, ZDV has been given to very few premature babies, and the best dose to use has not yet been determined.
|Condition or disease||Intervention/treatment||Phase|
|HIV Infections||Drug: Zidovudine||Not Applicable|
In the preliminary group of premature infants, those receiving q 6h dosing had an average trough concentration of 7.3 uM (18%). However, the premature infants in the preliminary pharmacokinetic study did not have long term follow-up to assess toxicity. Due to the potential for altered ZDV pharmacokinetics and increased toxicity in this population, an evaluation of ZDV pharmacokinetics in premature infants is proposed.
Premature infants less than or equal to 34 weeks gestational age at birth and begun on ZDV by their clinical caregivers will be entered into the protocol within the first 5 days of life. Upon entry, ZDV will be administered every 12 hours intravenously or orally. The study will require 9 serum samples for ZDV assay collected over 30 days, some additional clinical laboratory tests collected over 12 weeks, collection of 3 spot urine samples, and collection of routine clinical data.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||35 participants|
|Masking:||None (Open Label)|
|Official Title:||The Safety, Tolerance, and Pharmacokinetics of Zidovudine in Premature Infants Exposed to HIV.|
|Actual Study Completion Date :||February 2000|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000855
Show 36 Study Locations
|Study Chair:||Mirochnick M|
|Study Chair:||Dankner D|
|Study Chair:||Capparelli E|