The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient
|Study Design:||Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:||The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient|
Benzodiazepines (such as oxazepam) are among the most frequently prescribed class of drugs and are commonly used therapeutically for patients with chronic disease. This study is important because of the potential for toxicity resulting from a reaction between AZT and benzodiazepines and the likelihood of frequent use of the combination of these drugs in patients with HIV infection.
Patients are studied to determine oral and intravenous AZT and single oral dose oxazepam pharmacokinetics. Patients then take AZT and oxazepam together to determine if interactions between the drugs occur.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000661
|United States, California|
|Palo Alto Veterans Adm Med Ctr / Stanford Univ|
|Palo Alto, California, United States, 94304|
|Study Chair:||Israelski D|
|Study Chair:||Blaschke T|