An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 400/mm3)
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Purpose
To assess the safety and tolerance of multiple oral doses of nevirapine in combination with zidovudine (AZT); to get information on the pharmacokinetics (blood levels) and dose proportionality of nevirapine/AZT with multiple dosing; to characterize the pattern of virological activity in vivo (in humans) of nevirapine in combination with AZT; to determine whether development of resistance to either drug is slowed by the use of the combination.
Drugs now used in treatment for patients with AIDS show some toxicity which limits their usefulness. In addition, with long-term treatment with AZT, there is evidence of virus resistance to the drug. Compounds that are more effective and less toxic than those in present use would be beneficial, especially if they are active against AZT-resistant viruses. Nevirapine has shown in vitro (test tube studies) activity in inhibiting HIV replication (reproduction). In vitro studies have shown that nevirapine and AZT work together to inhibit HIV replication.
| Condition | Intervention | Phase |
|---|---|---|
|
HIV Infections |
Drug: Nevirapine Drug: Zidovudine |
Phase 1 |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Pharmacokinetics Study Primary Purpose: Treatment |
| Official Title: | An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 400/mm3) |
| Estimated Enrollment: | 30 |
Drugs now used in treatment for patients with AIDS show some toxicity which limits their usefulness. In addition, with long-term treatment with AZT, there is evidence of virus resistance to the drug. Compounds that are more effective and less toxic than those in present use would be beneficial, especially if they are active against AZT-resistant viruses. Nevirapine has shown in vitro (test tube studies) activity in inhibiting HIV replication (reproduction). In vitro studies have shown that nevirapine and AZT work together to inhibit HIV replication.
Groups of 10 patients are studied at each of three dose levels. Five patients at each dose level have less than 3 months of prior AZT treatment; five patients at each dose level have at least 12 months of previous AZT treatment and tolerated an AZT regimen of 600 mg/day (200 mg every 8 hours). At least 24 patient-weeks of treatment with the combination treatment must be completed without requiring dose interruption before the next dosage level can be started. All 30 patients must be enrolled at a lower dosage level before a higher dosage level is started. Patients begin treatment with AZT. 14 days later, patients begin treatment with nevirapine in addition to the AZT. After 24 weeks, patients have the option to continue long-term treatment with either nevirapine or standard treatment.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria
Concurrent Medication: Included:
Pneumocystis carinii pneumonia prophylaxis (other than sulfamethoxazole alone or in combination with other medications).
- Antifungal prophylaxis with oral fluconazole or ketoconazole.
- Antiviral prophylaxis with a maximum of 1 g/day oral acyclovir.
Patients must have the following:
- HIV infection.
- Ability to voluntarily provide written informed consent prior to treatment.
- Willing and able to follow protocol requirements.
- Patients with nonvisceral Kaposi's sarcoma or with visceral Kaposi's sarcoma not requiring chemotherapy and/or irradiation may be included.
Exclusion Criteria
Co-existing Condition:
Patients with the following conditions or symptoms are excluded:
- Radiographic evidence of chronic pulmonary disease.
- Cytomegalovirus disease.
- Toxoplasmosis encephalitis requiring suppressive therapy.
- Mycobacteriosis requiring maintenance chemotherapy.
- Visceral Kaposi's sarcoma requiring chemotherapy and/or irradiation.
Concurrent Medication:
Excluded:
- Glucocorticoids and steroid hormones (including oral contraceptives).
- Dicumarol, warfarin, and other anticoagulant medications.
- Nitroglycerin.
- Digitoxin.
- Valproic acid.
- Tolbutamide.
- Doxycycline.
- Chloramphenicol.
- Isoniazid.
- Antiepileptics (Phenobarbital and other barbiturates).
- Sulfonamides.
Excluded for up to 4 hours before and 4 hours after administration of drug 2:
- Antacids.
- Cimetidine.
- Carafate.
- Cholestyramine resin.
- Alcohol and alcohol-containing substances.
- Benzodiazepines (diazepam, triazolam).
Patients with the following are excluded:
- History of clinically important disease (defined as a disease that, in the opinion of the investigator, may either put the patient at risk because of participation in the study or a disease that may influence the results of the study or the patient's ability to participate in the study) other than HIV infection.
- Malignancy other than Kaposi's sarcoma or limited cutaneous basal cell carcinoma.
Prior Medication:
Excluded within 4 weeks prior to administration of study drug 2:
- Antiretroviral (other than zidovudine (AZT)), immunosuppressive, or cytotoxic drugs.
- Glucocorticoids and steroid hormones (including oral contraceptives).
- Dicumarol, warfarin, and other anticoagulant medications.
- Nitroglycerin.
- Digitoxin.
- Valproic acid.
- Tolbutamide.
- Doxycycline.
- Chloramphenicol Isoniazid.
- Antiepileptics (Phenobarbital and other barbiturates).
- Sulfonamides.
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00000649
| United States, Alabama | |
| Cooper Green Hosp | |
| Birmingham, Alabama, United States, 35233 | |
| United States, California | |
| Univ of California / San Diego Treatment Ctr | |
| San Diego, California, United States, 921036325 | |
| United States, Massachusetts | |
| Univ of Massachusetts | |
| Worcester, Massachusetts, United States, 01655 | |
| Study Chair: | Sarah Cheeseman |
More Information
Additional Information:
Publications:
| ClinicalTrials.gov Identifier: | NCT00000649 History of Changes |
| Other Study ID Numbers: | ACTG 168, 00834 |
| Study First Received: | November 2, 1999 |
| Last Updated: | July 29, 2008 |
| Health Authority: | Unspecified |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
|
Drug Therapy, Combination Acquired Immunodeficiency Syndrome AIDS-Related Complex Zidovudine Nevirapine |
Additional relevant MeSH terms:
|
Acquired Immunodeficiency Syndrome HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Lentivirus Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Virus Diseases Zidovudine |
Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antimetabolites Antiviral Agents Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Nucleic Acid Synthesis Inhibitors Pharmacologic Actions Reverse Transcriptase Inhibitors Therapeutic Uses |
ClinicalTrials.gov processed this record on March 03, 2015