Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: October 27, 1999
Last updated: December 1, 2005
Last verified: November 2005
To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.

Condition Intervention Phase
Atrial Fibrillation
Cardiovascular Diseases
Heart Diseases
Drug: amiodarone
Drug: sotalol
Drug: propafenone
Drug: flecainide
Drug: quinidine
Drug: moricizine
Drug: disopyramide
Drug: procainamide
Drug: adrenergic beta antagonists
Drug: verapamil
Drug: diltiazem
Drug: digoxin
Procedure: catheter ablation
Device: pacemaker, artificial
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: March 1995
Estimated Study Completion Date: September 2002
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Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Elderly men and women with atrial fibrillation and other risk factors for stroke.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00000556

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigator: H. Greene Statistics and Epidemiology Research Corporation (S.E.R.C.)
  More Information


Additional publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00000556     History of Changes
Other Study ID Numbers: 100 
Study First Received: October 27, 1999
Last Updated: December 1, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Atrial Fibrillation
Cardiovascular Diseases
Arrhythmias, Cardiac
Heart Diseases
Pathologic Processes
Adrenergic beta-Antagonists
Adrenergic Agents
Adrenergic Antagonists
Anti-Arrhythmia Agents
Cardiovascular Agents
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sodium Channel Blockers
Therapeutic Uses
Voltage-Gated Sodium Channel Blockers processed this record on February 10, 2016