Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00000252
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : May 28, 2015
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
University of Chicago

Brief Summary:
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.

Condition or disease Intervention/treatment Phase
Opioid-Related Disorders Substance-Related Disorders Drug: 0% N2O Drug: 10% N2O Drug: 20% N2O Drug: 30% N2O Drug: 40% N2O Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 11 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Lack of Acute Tolerance Development to Effects of Nitrous Oxide
Study Start Date : June 1994
Actual Primary Completion Date : June 1996
Actual Study Completion Date : June 1996

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Sham Comparator: 0% N2O
Subjects will inhale 0% N2O
Drug: 0% N2O
Active Comparator: 10% N2O
Subjects will inhale 10% N2O
Drug: 10% N2O
Active Comparator: 20% N2O
Subjects will inhale 20% N2O
Drug: 20% N2O
Active Comparator: 30% N2O
Subjects will inhale 30% N2O
Drug: 30% N2O
Active Comparator: 40% N2O
Subjects will inhale 40% N2O
Drug: 40% N2O

Primary Outcome Measures :
  1. Psychomotor performance [ Time Frame: During inhalation ]
    Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention

  2. Cognitive performance [ Time Frame: During inhalation ]
    Subjects will under cognitive testing during 120 minute inhalation session of each intervention

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Ages Eligible for Study:   21 Years to 29 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00000252

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
National Institute on Drug Abuse (NIDA)
Principal Investigator: James Zacny, Ph.D. University of Chicago

Responsible Party: University of Chicago Identifier: NCT00000252     History of Changes
Other Study ID Numbers: NIDA-08391-4
R01DA008391 ( U.S. NIH Grant/Contract )
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: May 28, 2015
Last Verified: May 2015

Keywords provided by University of Chicago:
nitrous oxide
acute tolerance
subjective effects
healthy volunteer

Additional relevant MeSH terms:
Substance-Related Disorders
Opioid-Related Disorders
Pathologic Processes
Chemically-Induced Disorders
Mental Disorders
Nitrous Oxide
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents