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Alternate-Day Buprenorphine Administration. Phase II - 4

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ClinicalTrials.gov Identifier: NCT00000222
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : June 24, 2005
Sponsor:
Collaborator:
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to determine if two times a subject's daily maintenance dose will hold for 48 hours without changes in agonist and antagonist effects.

Condition or disease Intervention/treatment Phase
Opioid-Related Disorders Drug: Buprenorphine Phase 1

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 0 participants
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
Official Title: Alternate-Day Buprenorphine Administration. Phase II
Study Start Date : July 1992

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions


Outcome Measures

Primary Outcome Measures :
  1. Drug use
  2. Opioid withdrawal
  3. Opioid agonist effects
  4. Dose identification
  5. Pupil diameter

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   28 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
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Contacts and Locations

Information from the National Library of Medicine

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000222


Locations
United States, Vermont
Treatment Research Center
Burlington, Vermont, United States, 05401
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
University of Vermont
Investigators
Principal Investigator: Warren Bickel, Ph.D. University of Vermont
More Information

Publications:
Amass, bickel, Crean, Blake, Higgins (in press). Alternate day buprenorphine dosing as efficacious and preferred to daily dosing in opioid dependent humans. Psychopharmacology. Amass, Bickel, Crean, Blake, Higgins. (in press) Alternate day buprenorphine dosing as efficacious and preferred to daily dosing in opioid dependent humans. Psychopharmacology

ClinicalTrials.gov Identifier: NCT00000222     History of Changes
Other Study ID Numbers: NIDA-06969-4
R01-06969-4
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 1993

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Buprenorphine
Analgesics, Opioid
Narcotics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Narcotic Antagonists