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Cocaine Effects in Humans: Physiology and Behavior - 1

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ClinicalTrials.gov Identifier: NCT00000200
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : January 12, 2017
Columbia University
Information provided by:
National Institute on Drug Abuse (NIDA)

Brief Summary:
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving, in opiate-dependent cocaine users.

Condition or disease Intervention/treatment Phase
Cocaine-Related Disorders Drug: Methadone Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 19 participants
Intervention Model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
Official Title: Cocaine Effects in Humans: Physiology and Behavior
Study Start Date : January 1997
Primary Completion Date : January 1998
Study Completion Date : January 1998

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Intervention Details:
    Drug: Methadone
    normal maintenance dose

Primary Outcome Measures :
  1. Interaction of cocaine and meds on cardio [ Time Frame: 3 hr ]
  2. Interaction of cocaine & meds on coc's subjective [ Time Frame: 3 hr ]
  3. Effects of medication on cocaine craving [ Time Frame: 3 hr ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000200

United States, New York
Columbia University
New York, New York, United States, 10023
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
Columbia University
Principal Investigator: Marian Fischman, Ph.D. Columbia University

ClinicalTrials.gov Identifier: NCT00000200     History of Changes
Other Study ID Numbers: NIDA-03818-1
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: January 12, 2017
Last Verified: October 2016

Keywords provided by National Institute on Drug Abuse (NIDA):

Additional relevant MeSH terms:
Cocaine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents
Analgesics, Opioid
Antitussive Agents
Respiratory System Agents