| 1 |
NCT01018680 |
Completed
Has Results |
A Study Comparing Duloxetine Versus Placebo in Patients Taking a Nonsteroidal Anti-inflammatory Drug (NSAID) for Knee Pain Due to Osteoarthritis |
|
- Drug: Duloxetine
- Drug: Placebo
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Baseline in the Weekly Mean of the 24-Hour Average Pain Score at 8 Weeks
- Patient Global Impression of Improvement (PGI-I) at 8 Weeks
- Change From Baseline in the Western Ontario and McMaster Universities Index of Osteoarthritis (WOMAC) Pain, Stiffness, and Physical Function Subscale Scores at 8 Weeks
- (and 10 more...)
|
524 |
All |
40 Years and older (Adult, Senior) |
NCT01018680 |
12909
F1J-US-HMGL |
|
November 2009 |
April 2011 |
April 2011 |
November 25, 2009 |
October 5, 2012 |
October 5, 2012 |
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Tucson, Arizona, United States - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Garden Grove, California, United States - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Long Beach, California, United States - (and 32 more...)
|
| 2 |
NCT02141529 |
Completed |
Intraarticular Pulse Radiofrequency to Treat Chronic Knee Pain |
|
- Procedure: Unipolar pulsed radiofrequency thermocoagulation
- Procedure: Bipolar pulsed radiofrequency thermocoagulation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Visual Analog Scale scores to measure the pain degree
- WOMAC scores to measure the degree of quality of life and the functional response of treatment of patients
|
100 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT02141529 |
IAPRF01 |
|
May 2014 |
December 2015 |
December 2015 |
May 19, 2014 |
March 17, 2016 |
|
- Cukurova University Faculty of Medicine Research Hospital
Adana, Turkey
|
| 3 |
NCT01619150 |
Completed |
A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain |
|
- Drug: Etoricoxib, followed by placebo (matching tablet, without active ingredient)
- Drug: Placebo (matching tablet, without active ingredient), followed by etoricoxib
|
Interventional |
Phase 2 |
- C4Pain
- Merck Sharp & Dohme Corp.
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Basic Science
|
- Change in Experimental mechanism based Pain Measures (EPMs)during two treatment periods of 4-weeks each
- Change in Clinical Outcome measures during two treatment periods of 4-weeks each
|
39 |
All |
40 Years to 75 Years (Adult, Senior) |
NCT01619150 |
OSKNEEPA02 |
|
July 2012 |
July 2013 |
July 2013 |
June 14, 2012 |
July 23, 2013 |
|
|
| 4 |
NCT03389906 |
Recruiting |
Inflammation Impact on Pain in Knee Osteoarthritis |
- Inflammation
- Osteo Arthritis Knee
|
|
Interventional |
Not Applicable |
- Sten Rasmussen, MD, PhD
- Aalborg University
- Northern Orthopaedic Division, Denmark
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Inflammatory markers
- Quantitative sensory testing
- Weekly pain diary
- (and 2 more...)
|
20 |
All |
40 Years to 75 Years (Adult, Senior) |
NCT03389906 |
N-20160045 |
|
December 1, 2017 |
December 2018 |
December 2018 |
January 4, 2018 |
January 4, 2018 |
|
- Aalborg University Hospital
Aalborg, Denmark
|
| 5 |
NCT02917655 |
Active, not recruiting |
P.A.R.Q.V.E III - Comparison of the Educational Program With and Without Multidisciplinary Care |
- Osteoarthritis
- Metabolic Diseases
|
- Behavioral: Womac
- Behavioral: Lequesne
- Behavioral: VAS
- (and 10 more...)
|
Interventional |
Not Applicable |
- University of Sao Paulo General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Evaluate function with the TUG (Time-up-Go test)
- Evaluate improvement in pain
- Evaluate improvement in function
- (and 4 more...)
|
90 |
All |
45 Years to 75 Years (Adult, Senior) |
NCT02917655 |
14833/16 |
PARQVE3 |
November 2016 |
November 2018 |
November 2018 |
September 28, 2016 |
January 16, 2017 |
|
|
| 6 |
NCT02284620 |
Unknown † |
Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Total Knee Arthroplasty --- A Randomized Controlled Trial |
- Postoperative Pain
- Total Knee Arthroplasty
|
- Procedure: CFNB group
- Procedure: LWI group
|
Interventional |
Phase 4 |
- First Affiliated Hospital of Chongqing Medical University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- chronic moderate-to-severe post-surgical pain
- acute pain post-operatively
- Analgesic Rescue
- (and 3 more...)
|
320 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02284620 |
CYYYMZ-001 |
|
January 2015 |
July 2015 |
June 2017 |
November 6, 2014 |
July 28, 2015 |
|
- The First Affliated Hospital of Chongqing Medical University
Chongqing, Chongqing, China
|
| 7 |
NCT01826305 |
Unknown † |
Independent Exercise Compared With Formal Rehabilitation Following Primary Total Knee Replacement |
- Recovery Following Primary Total Knee Arthroplasty
|
- Procedure: Formal Rehabilitation Therapy
- Procedure: Independent Exercise Cohort
|
Interventional |
Not Applicable |
- University of California, San Francisco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Knee Function
- General physical and mental health
- Activity Level
- Knee and Osteoarthritis Outcome Score (KOOS)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT01826305 |
12-09642 |
|
July 2014 |
July 2015 |
|
April 8, 2013 |
August 18, 2014 |
|
- University of California, San Francisco
San Francisco, California, United States
|
| 8 |
NCT00556608 |
Completed |
Efficacy Study of Intra-articular Hyaluronic Acid in the Knee Osteoarthritis |
|
- Device: Sinovial® (syringe containing sodium hyaluronate solution)
- Device: Synvisc® ( syringe containing Hylan G-F 20 solution)
|
Interventional |
Phase 4 |
- IBSA Institut Biochimique SA
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Improvement in WOMAC pain subscore from baseline
- Change in WOMAC OA Index total score and pain, function and stiffness subscores;Change in Lequesne's algofunctional index; Change in global pain (visit assessment); Change in global status by the patient;Change in global status by the Investigator;SPID%
|
381 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT00556608 |
06CZIFCH/Hai06 |
|
November 2007 |
July 2009 |
May 2010 |
November 12, 2007 |
December 4, 2012 |
|
- Interni hemato-onkologická klinika, Fakultní nemocnice
Brno - Bohunice, Czech Republic - ARTHROMED s.r.o.
Pardubice, Czech Republic - Institute of Rheumatology
Praha, Czech Republic - (and 17 more...)
|
| 9 |
NCT00435773 |
Completed |
Leeches for the Treatment of Knee Osteoarthritis |
|
- Procedure: Single Leeching
- Procedure: Repeated Leeching after 4 weeks
- Procedure: Placebo Leeching
|
Interventional |
Phase 2 |
- RWTH Aachen University
- University Hospital, Aachen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single
- Primary Purpose: Treatment
|
- KOOS Score overall (Clinical score)before intervention, after 1,4 and 6 weeks, 3 and 6 months
- WOMAC Score overall (Clinical score)before intervention, after 1,4 and 6 weeks, 3 and 6 months
- VAS (Visual analog scale, pain score)before intervention, after 1,4 and 6 weeks, 3 and 6 months
- (and 4 more...)
|
118 |
All |
Child, Adult, Senior |
NCT00435773 |
EK 102/03 |
|
February 2004 |
|
December 2004 |
February 15, 2007 |
April 9, 2007 |
|
- Department of Orthopaedic Surgery, University Hospital of the RWTH Aachen, Germany
Aachen, Germany
|
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