Plasma concentrations of unchanged clopidogrel, its active thiol metabolite and its inactive carboxyl metabolite between the different patient groups after the administration of a 600 mg loading dose of clopidogrel.
The magnitude of platelet reactivity as measured with several commercial available platelet function tests before and 6 hours after the ingestion of the loading dose.
Exploratory Endpoint: prevalence of various genetic polymorphisms that might influence the pharmacokinetics of clopidogrel
18 Years to 90 Years (Adult, Senior)
November 13, 2009
August 23, 2011
St Antonius Hospital Nieuwegein, Utrecht, Netherlands
† Study has passed its completion date and status has not been verified in more than two years.