National Institutes of Health Clinical Center (CC)
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Determine the response rate (CR+PR) of PF-03084014 in patients with desmoid tumors/aggressive fibromatosis
Assess symptom measures at baseline and on study; perform genotyping for germline and somatic mutations in APC and CTNNB1 genes; correlate clinical response to therapy with genotyping data; and assess modulation of the Notch pathway by evaluatin...
18 Years to 120 Years (Adult, Senior)
October 31, 2013
December 30, 2018
October 12, 2019
November 11, 2013
February 14, 2018
National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States
† Study has passed its completion date and status has not been verified in more than two years.