| 1 |
NCT00258115 |
Completed |
The Study of Inflammation on Blood Glucose Levels in Obese People |
|
|
Interventional |
Phase 2 |
- Joslin Diabetes Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
|
20 |
All |
18 Years to 30 Years (Adult) |
NCT00258115 |
CHS 03-48 |
|
December 2003 |
October 2007 |
|
November 24, 2005 |
February 15, 2018 |
|
- Joslin Diabetes Center
Boston, Massachusetts, United States
|
| 2 |
NCT00258128 |
Completed |
Effect of Salicylate on Glucose Metabolism in Insulin Resistance States |
|
|
Interventional |
Phase 2
Phase 3 |
- Joslin Diabetes Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
|
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT00258128 |
CHS 00-01 |
|
January 2000 |
|
|
November 24, 2005 |
November 27, 2008 |
|
|
| 3 |
NCT00392678 |
Completed
Has Results |
Targeting INflammation Using SALsalate in Type 2 Diabetes (TINSAL-T2D) |
|
- Drug: Salsalate
- Drug: Placebo
|
Interventional |
Phase 2
Phase 3 |
- Joslin Diabetes Center
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Primary Outcome for the TINSAL-T2D Study is Change in HbA1c Level From Baseline to Week 14 (Stage 1) in the Intent-to-treat (ITT) Population With Last Observation Carried Forward.
- Change From Baseline to Either 14 or 26 Weeks, or Last HbA1c Measurement Prior to Rescue Therapy
- Change From Baseline and Trends in Fasting Glucose Over Time
- (and 9 more...)
|
277 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00392678 |
CHS 06-20, NIH U01 DK74556
U01DK074556 |
TINSAL-T2D |
October 2006 |
July 2008 |
December 2010 |
October 26, 2006 |
December 11, 2017 |
July 26, 2013 |
- Chapel Medical Group
New Haven, Connecticut, United States - MedStar Research Institute
Washington, District of Columbia, United States - Endocrine Clinical Research
Winter Park, Florida, United States - (and 13 more...)
|
| 4 |
NCT00799643 |
Completed
Has Results |
Targeting Inflammation Using Salsalate for Type 2 Diabetes-Stage II |
|
- Drug: Salsalate
- Drug: Salsalate Placebo
|
Interventional |
Phase 2
Phase 3 |
- Joslin Diabetes Center
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Primary Outcome for the TINSAL-T2D Study is Change in HbA1c Level From Baseline to Week 48 From Baseline, Compared Between Treatment Groups.
- Change From Baseline in Fasting Glucose Over Time.
- Response Rates for Reduction in Fasting Glucose of ≥20 mg/dl, a Reduction in HbA1c of ≥0.5%, and a Reduction in HbA1c of ≥0.8%
- (and 4 more...)
|
638 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00799643 |
CHS 06-20-2
U01DK074556 |
TINSALT2D-II |
November 2008 |
September 2012 |
|
December 1, 2008 |
December 11, 2017 |
November 25, 2013 |
- University of Alabama
Birmingham, Alabama, United States - University of California, San Diego
San Diego, California, United States - Chapel Medical Group
New Haven, Connecticut, United States - (and 18 more...)
|
| 5 |
NCT00624923 |
Active, not recruiting
Has Results |
Targeting Inflammation Using Salsalate in CardioVascular Disease |
- Coronary Artery Disease
- Overweight
|
- Drug: Salsalate
- Drug: Placebo
|
Interventional |
Phase 2
Phase 3 |
- Joslin Diabetes Center
- Beth Israel Deaconess Medical Center
- Tufts Medical Center
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Non-calcified Plaque Volume in the Coronary Arteries Assessed by MDCTA From Baseline to 30 Months
- Change in the Metabolic Syndrome Assessed by Measures by Waist/Hip Ratio, Systolic and Diastolic Blood Pressure, Lipid Profiles (Total Cholesterol, Triglycerides, HDL and LDL), and Abdominal Adiposity Quantitated by Computerized Tomography
- Reduction of Mediators of Inflammation in the Circulation (Such as CRP), and Markers of Oxidative Stress.
- (and 7 more...)
|
340 |
All |
21 Years to 75 Years (Adult, Senior) |
NCT00624923 |
CHS 06-13
P50HL083813
CCI: 2006-P-00175
CHS: 06-13 |
TINSAL-CVD |
September 2008 |
January 2015 |
December 2019 |
February 28, 2008 |
December 12, 2017 |
December 12, 2017 |
- Seacoast Cardiology
York, Maine, United States - Joslin Diabetes Center
Boston, Massachusetts, United States - Heart Center of Metrowest
Framingham, Massachusetts, United States - (and 2 more...)
|
| 6 |
NCT03173677 |
Completed |
Macrophage Polarization in Response to Macronutrient Intake in Healthy Humans: A Randomized Clinical Study |
|
- Dietary Supplement: Lipid Intake
- Dietary Supplement: Glucose intake
- Dietary Supplement: Protein intake
|
Interventional |
Not Applicable |
- King Saud Bin Abdulaziz University for Health Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Detection of markers of M1 and M2 macrophages
|
36 |
All |
18 Years and older (Adult, Senior) |
NCT03173677 |
SP15/026 |
|
February 2, 2016 |
April 24, 2016 |
April 29, 2016 |
June 2, 2017 |
June 2, 2017 |
|
|
| 7 |
NCT03004079 |
Recruiting |
Clinical Importance of Glucose Regulation in Relapsing MS |
- Relapsing Remitting Multiple Sclerosis
- Clinically Isolated Syndrome
|
|
Observational |
|
- University of Virginia
- National Multiple Sclerosis Society
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Relapse Recovery & Hyperglycemia
- Insulin Resistance & Relapse Severity
|
160 |
All |
18 Years to 59 Years (Adult) |
NCT03004079 |
19259 |
|
October 2016 |
September 2020 |
September 2020 |
December 28, 2016 |
January 10, 2017 |
|
- University of Virginia
Charlottesville, Virginia, United States
|
| 8 |
NCT02975258 |
Completed |
Adiposity and Airway Inflammation in HIV-Associated Airway Disease |
|
- Procedure: Blood draw
- Other: Questionnaires
- Procedure: Spirometry
- (and 5 more...)
|
Observational |
|
- University of Pittsburgh
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Adverse interaction of adiposity and HIV-associated inflammation in asthma susceptibility and airway remodeling in HIV
- Correlation between leptin and asthma susceptibility in HIV.
- Correlation between adiponectin, asthma susceptibility, and airway remodeling in HIV.
- (and 3 more...)
|
102 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02975258 |
PRO15070529
1R56HL128134-01A1 |
SHOP |
September 2015 |
September 2017 |
September 2017 |
November 29, 2016 |
October 13, 2017 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
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