| 1 |
NCT00099840 |
Completed |
Procalcitonin Guided Antibiotic Use in Acute Respiratory Tract Infections (PARTI)-Study |
- Respiratory Tract Infections
|
- Procedure: Procalcitonin guided antibiotic therapy
|
Interventional |
Not Applicable |
- University Hospital, Basel, Switzerland
- Basel Institute of Clinical Epidemiology (BICE)
- Brahms AG
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Days with restrictions from ARTI
- Rate of AB prescriptions
- days with AB use
- (and 4 more...)
|
400 |
All |
18 Years and older (Adult, Senior) |
NCT00099840 |
PARTIS |
|
December 2004 |
|
April 2006 |
December 21, 2004 |
April 25, 2007 |
|
- University Hospital
Basel, CH, Switzerland
|
| 2 |
NCT00415753 |
Completed |
Procalcitonin as a Marker of Bacterial Pneumonia |
|
- Behavioral: No antibiotics if se-procalcitonin is below stated limit
|
Interventional |
Not Applicable |
- Aarhus University Hospital Skejby
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Antibiotic use
- Length of stay in hospital
- The proportion of patients where the doctor chooses to disregard treatment guidelines
|
223 |
All |
18 Years and older (Adult, Senior) |
NCT00415753 |
271-05-0765 |
|
June 2006 |
April 2007 |
August 2007 |
December 25, 2006 |
May 23, 2008 |
|
- Department of Infectious Diseases, Skejby Hospital
Aarhus N, Denmark - Departement of Medicin, Silkeborg Hospital
Silkeborg, Denmark
|
| 3 |
NCT03440060 |
Recruiting |
Procalcitonin-guided Antibiotic Therapy During Severe Acute Exacerbation of COPD |
|
- Diagnostic Test: procalcitonin
|
Interventional |
Not Applicable |
- University Hospital, Mahdia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- time to recovery
- Antibiotic exposure at day 90
- Hospital readmission for another exacerbation at day 90
- (and 4 more...)
|
100 |
All |
40 Years and older (Adult, Senior) |
NCT03440060 |
301401 |
|
October 5, 2017 |
October 1, 2019 |
December 31, 2019 |
February 20, 2018 |
February 21, 2018 |
|
- Tilouche Nejla
Mahdia, Tunisia
|
| 4 |
NCT00398775 |
Terminated |
Procalcitonin in Fever of Unknown Etiology |
|
- Procedure: antibiotic discontinuation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Exposure to systemic antimicrobial treatment:
- duration of antibiotic treatment (in days).
- total antibiotic exposure (in defined daily doses).
- (and 5 more...)
|
90 |
All |
21 Years and older (Adult, Senior) |
NCT00398775 |
2006/36 |
|
January 2007 |
|
September 2007 |
November 14, 2006 |
November 20, 2007 |
|
- Changi General Hospital
Singapore, Singapore
|
| 5 |
NCT03332225 |
Recruiting |
A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis |
- Sepsis
- Macrophage Activation Syndrome
|
- Drug: Anakinra
- Drug: Recombinant human interferon-gamma
- Drug: Placebo
|
Interventional |
Phase 2 |
- Hellenic Institute for the Study of Sepsis
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mortality
- Time to decrease of SOFA score by more than 50%
- Time to infection resolution
- (and 6 more...)
|
278 |
All |
18 Years and older (Adult, Senior) |
NCT03332225 |
PROVIDE
2017-002171-26 |
PROVIDE |
December 15, 2017 |
November 14, 2019 |
May 14, 2020 |
November 6, 2017 |
January 9, 2018 |
|
- 2nd Department of Critical Care Medicine
Athens, Haidari, Greece - 4th Department of Internal Medicine
Athens, Haidari, Greece - Intensive Care Unit, Ioannina University Hospital
Ioánnina, Ioannina, Greece - (and 8 more...)
|
| 6 |
NCT03322670 |
Recruiting |
Description of Pneumococcal Pneumonia |
- Community-acquired Pneumonia
|
- Other: Signs of CAP and a positive chest X-Ray
- Other: Patients directly hospitalized
- Diagnostic Test: Control patients
- (and 2 more...)
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Percentage of pneumococcal CAP amongst the other etiological CAP with a positive chest X-ray
- Description of clinical characteristics of patients treated in general practice for a radiologically confirmed CAP, based on the microbiological etiologies
|
2400 |
All |
18 Years and older (Adult, Senior) |
NCT03322670 |
N° ID RCB : 2016-A01537-44 |
PneumoCAP |
December 21, 2017 |
March 2019 |
May 2019 |
October 26, 2017 |
January 8, 2018 |
|
- URC-CIC Paris Descartes-Cochin-Necker
Paris, France
|
| 7 |
NCT00407147 |
Terminated |
Procalcitonin Level to Discontinue Antibiotics on ICU Patients With no Obvious Site of Infection |
- Infection
- Bacterial Infection
- Sepsis
|
- Device: Procalcitonin assay - B.R.A.H.M.S PCT sensitive Kryptor
|
Interventional |
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Days on antibiotics beginning with day 4 until the first day without antibiotics (up to max. 28 days follow up)
- Days on antibiotics during ICU stay
- Sepsis classification
- (and 4 more...)
|
11 |
All |
18 Years and older (Adult, Senior) |
NCT00407147 |
ProBac |
|
July 2008 |
June 2009 |
June 2009 |
December 4, 2006 |
January 18, 2012 |
|
- Saint Louis University - medical intensive care unit
Saint Louis, Missouri, United States - Cooper University Hospital
Camden, New Jersey, United States - Rhode Island Hospital
Providence, Rhode Island, United States
|
| 8 |
NCT02173613 |
Unknown † |
Reduction the Duration of Antibiotic Therapy in the Elderly (PROPAGE) |
|
|
Interventional |
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Duration of antibiotic therapy
|
340 |
All |
80 Years and older (Senior) |
NCT02173613 |
1120 |
PROPAGE |
August 2012 |
December 2015 |
March 2016 |
June 25, 2014 |
June 25, 2014 |
|
- University Hospital Grenoble
Grenoble, Rhone alpes, France
|
| 9 |
NCT02130986 |
Completed |
Procalcitonin Antibiotic Consensus Trial (ProACT) |
- Lower Respiratory Tract Infection (LRTI)
|
- Other: Procalcitonin level
- Other: Results of procalcitonin (PCT) level to treating clinician
- Other: Provide procalcitonin guideline to treating clinician
- Other: Telephone Visit
|
Interventional |
Not Applicable |
- University of Pittsburgh
- National Institute of General Medical Sciences (NIGMS)
- BioMérieux
|
Other / NIH / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Total antibiotic exposure days
- Combined endpoint of adverse outcomes that could be attributable to withholding antibiotics in LRTI
- Rate of antibiotic initiation by the initial ED clinician
|
1664 |
All |
18 Years and older (Adult, Senior) |
NCT02130986 |
1R01GM101197 |
ProACT |
November 3, 2014 |
July 10, 2017 |
July 10, 2017 |
May 6, 2014 |
August 10, 2017 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Maricopa Medical Center
Phoenix, Arizona, United States - University of California at Irvine Medical Center
Orange, California, United States - (and 10 more...)
|
| 10 |
NCT01788488 |
Completed |
Procalcitonin Use in Pneumonia Patients in the Critical Care Setting |
|
- Other: Use of procalcitonin as biomarker to guide therapy
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Length of antibiotic therapy
- Length of stay in critical care unit
- Cost
- Length of stay in the hospital
|
134 |
All |
18 Years and older (Adult, Senior) |
NCT01788488 |
12-008835 |
|
February 2013 |
March 2013 |
June 2013 |
February 11, 2013 |
June 25, 2013 |
|
- Mayo Clinic Health System Eau Claire
Eau Claire, Wisconsin, United States
|
| 11 |
NCT00350987 |
Completed |
Procalcitonin Guided Antibiotic Therapy and Hospitalisation in Patients With Lower Respiratory Tract Infections: The "ProHOSP" Study |
- Lower Respiratory Tract Infection
- Pneumonia
- Bronchitis
|
- Behavioral: a strategy based on PCT guided AB therapy
|
Interventional |
Not Applicable |
- University Hospital, Basel, Switzerland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- the risk of disease specific failure
- time to AB treatment/prescription rate, duration, rate and doses, first change, side-effects, hospitalization and discharge
- clinical stability, disease activity score, restriction days, function/health state, prediction rules and diagnostic and prognostic accuracy
|
1002 |
All |
18 Years and older (Adult, Senior) |
NCT00350987 |
EKBB87/06 |
|
October 2006 |
June 2008 |
June 2008 |
July 12, 2006 |
September 23, 2008 |
|
- University Hospital in Basel
Basel, BS, Switzerland
|
| 12 |
NCT00870623 |
Unknown † |
Procalcitonin and Endotoxin Sequential Levels to Optimize the Treatment of Bloodstream Infections |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To determine the optimal length of treatment by observing the normalization of procalcitonin (PCT) and Endotoxin levels, compared with the length of treatment by standard of care.
- To determine if procalcitonin and endotoxin levels (or lack of decrease) are associated with treatment failure, complication, survival, cost, length of stay, progression to severe sepsis, or superinfections.
|
136 |
All |
19 Years and older (Adult, Senior) |
NCT00870623 |
540-08-FB |
|
June 2009 |
June 2011 |
|
March 27, 2009 |
March 2, 2011 |
|
- The Nebraska Medical Center
Omaha, Nebraska, United States
|
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