Measure Insulin Resistance (IR) and clearance its effects on lipid metabolism, inflammatory response, and oxidative stress using intravenous glucose tolerance testing in patients with NAFLD as compared to matched controls.
Determine if IR is associated with altered parameters of lipid metabolism as compared to matched controls
Measure the differential effects of IR and lipid metabolism on peripheral mononuclear cell (PBMC) inflammatory response and the associated hepatocyte mitochondrial ultrastructure and measures of oxidative stress.
18 Years to 75 Years (Adult, Senior)
Pro00006742 NIH K23 Award 8592
March 29, 2013
April 13, 2017
March 18, 2008
July 11, 2017
Duke University Medical Center Durham, North Carolina, United States
† Study has passed its completion date and status has not been verified in more than two years.