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25 studies found for:    Open Studies | "alpha 1-Antitrypsin Deficiency"

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Rank Status Study
1 Recruiting Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (AATD)
Conditions: Liver Fibrosis;   Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD
Interventions: Device: Abdominal ultrasound;   Procedure: History and physical;   Procedure: Intravenous catheter;   Procedure: Blood draw;   Other: Liver questionnaire;   Procedure: Liver Biopsy;   Drug: Midazolam;   Drug: Fentanyl;   Drug: Lidocaine;   Drug: Acetaminophen;   Drug: Lorazepam;   Drug: Oxycodone/Acetaminophen;   Drug: Ondansetron
2 Recruiting Alpha-1 Antitrypsin Deficiency Adult Liver Study
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Procedure: Liver Biopsy
3 Not yet recruiting Microbioma in Sputa From COPD With Alpha-1 Antitrypsin Deficiency
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Other: collection of sputum
4 Recruiting Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency
Conditions: Alpha-1-antitrypsin Deficiency;   Liver Cirrhosis
Interventions: Drug: Drug-Carbamazepine (Tegretol XR);   Drug: Carbamazepine (Tegretol XR) Placebo
5 Not yet recruiting Safety Study of Gene Transfer Vector to Treat alpha1-antitrypsin Deficiency
Condition: alpha1-antitrypsin Deficiency
Intervention: Genetic: AAVrh.10halpha1AT
6 Recruiting A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD)
Condition: Alpha-1 Antitrypsin Deficiency
Interventions: Drug: ARC-AAT Injection;   Other: Placebo
7 Unknown † Endoscopic Lung Volume Reduction in Patients With Advanced Emphysema Due to alpha1 Antitrypsin Deficiency
Condition: Hereditary Emphysema (Alpha 1-antitrypsin Deficiency)
Intervention: Device: Implantation of intrabronchial valves (IBV) (Spiration IBV)
8 Recruiting Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention:
9 Unknown † Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema
Conditions: Alpha 1-Antitrypsin Deficiency;   Emphysema
Intervention:
10 Recruiting Safety and Pharmacokinetics of Alpha-1 MP in Patients With Alpha1-Antitrypsin Deficiency
Condition: Alpha1-Antitrypsin Deficiency
Intervention: Biological: Alpha-1 MP
11 Not yet recruiting Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency
Condition: Alpha1-Antitrypsin Deficiency
Intervention: Biological: Alpha-1 MP
12 Recruiting Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
Conditions: Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD;   Cystic Fibrosis (CF)
Interventions: Procedure: History and physical exam.;   Procedure: Blood draw.;   Procedure: Pulmonary function testing.;   Drug: Albuterol inhaler.
13 Recruiting Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency
Conditions: Alpha-1-Antitrypsin Deficiency;   Chronic Obstructive Lung Disease;   Emphysema
Intervention: Device: Lung Volume Reduction Coil (PneumrX Inc.)
14 Recruiting Environment Effect on Six-Minute Walk Test Performance
Conditions: Chronic Obstructive Pulmonary Disease;   Alpha-1 Antitrypsin Deficiency
Interventions: Other: six-minute walk study indoors;   Other: six-minute walk study outdoors
15 Not yet recruiting Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Drug: ARC-AAT Injection
16 Recruiting Ph 3/4 GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study
Condition: Alpha1-antitrypsin Deficiency
Intervention: Biological: GLASSIA
17 Recruiting Stage 1 Study of ARALAST NP and GLASSIA in A1PI
Conditions: Chronic Obstructive Pulmonary Disease;   Alpha1-antitrypsin Deficiency
Interventions: Biological: ARALAST NP 60 mg/kg;   Biological: ARALAST NP 120 mg/kg;   Biological: GLASSIA 60 mg/kg;   Biological: GLASSIA 120 mg/kg;   Biological: Human Albumin 2%
18 Recruiting Alpha-1 Carrier Genomics Study
Conditions: Alpha-1 Antitrypsin Deficiency;   Emphysema;   COPD;   Smoking
Intervention: Genetic: Genetic Sequencing
19 Recruiting Alpha-1 Coded Testing(ACT) Study
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Procedure: Alpha-1 Antitrypsin Genotype
20 Recruiting Alpha-1 Foundation Research Registry
Condition: Alpha 1-Antitrypsin Deficiency
Intervention:
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† Indicates status has not been verified in more than two years