24 studies found for:    Open Studies | "Shy-Drager Syndrome"
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1 Recruiting PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
Conditions: Multiple System Atrophy - Parkinsonian Subtype (MSA-P);   Multiple System Atrophy - Cerebellar Subtype (MSA-C)
Intervention:
2 Recruiting Oligomeric Alpha-synuclein in Multiple System Atrophy
Condition: Multiple System Atrophy (MSA)
Intervention:
3 Recruiting Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy
Condition: Multiple System Atrophy
Interventions: Other: Clinical evaluation;   Other: neuropsychological battery test;   Other: MRI;   Other: Actigraphy
4 Recruiting Water and Sudafed in Autonomic Failure
Conditions: Shy-Drager Syndrome;   Multiple System Atrophy
Interventions: Drug: Pseudoephedrine + 480 ml water;   Drug: Pseudoephedrine + 50 ml water;   Other: Placebo + 480 ml water (optional);   Other: Placebo + 50 ml water (optional)
5 Recruiting Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) Study
Condition: Multiple System Atrophy
Interventions: Radiation: PET (Positron Emission Tomography) Study;   Other: Brain MRI (magnetic resonance imaging);   Drug: Fluoxétine / Placebo
6 Unknown  Fipamezole in Neurogenic Orthostatic Hypotension
Conditions: Symptomatic Neurogenic Orthostatic Hypotension (NOH);   Parkinson's Disease;   Multiple System Atrophy
Interventions: Drug: Placebo;   Drug: Fipamezole
7 Recruiting Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA
Condition: Multiple System Atrophy
Interventions: Drug: L-Threo DOPS;   Drug: placebo
8 Recruiting AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA Patients
Condition: Multiple System Atrophy (MSA)
Interventions: Drug: AZD3241;   Drug: Placebo
9 Recruiting Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure
Conditions: Autonomic Nervous System Disorders;   Pure Autonomic Failure;   Shy-Drager Syndrome;   Orthostatic Hypotension, Dysautonomic
Interventions: Drug: Angiotensin-(1-7);   Drug: Saline
10 Recruiting Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA
Conditions: Multiple System Atrophy;   Neurodegenerative Diseases
Interventions: Biological: AFFITOPE® PD01A + Adjuvant;   Biological: AFFITOPE® PD03A + Adjuvant;   Biological: Adjuvant without active component
11 Recruiting Biomarkers in Parkinsonian Syndromes
Conditions: Parkinsonian Syndromes;   Parkinson's Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy
Interventions: Other: CSF, blood and urine sampling;   Other: clinical measures of disease severity and progression
12 Not yet recruiting Unique Brainstem Biomarkers of Early Parkinson's Disease
Conditions: Parkinson's Disease;   Alzheimer's Disease;   Progressive Supranuclear Palsy;   Essential Tremor;   Multiple System Atrophy;   Drug Induced Parkinson's Disease;   Diffuse Lewy Body Disease;   Myasthenia Gravis
Interventions: Other: Electrical Brainstem Responses;   Other: Olfactory Tests;   Other: Visual Deprivation
13 Recruiting Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
Conditions: Multiple System Atrophy;   Orthostatic Hypotension;   Supine Hypertension
Interventions: Drug: Trimethaphan;   Drug: Placebo
14 Recruiting Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease
Conditions: Parkinson Disease;   Multiple System Atrophy;   REM Sleep Behavior Disorder;   Pure Autonomic Failure;   Dementia With Lewy Bodies
Intervention:
15 Recruiting Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes
Conditions: Parkinson's Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy;   Vascular Parkinsonism
Intervention: Other: MRI exam of the brain
16 Recruiting Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Conditions: Orthostatic Hypotension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions: Other: Abdominal compression;   Other: Sham abdominal compression;   Drug: Placebo pill;   Drug: midodrine
17 Recruiting Local Heat Stress in Autonomic Failure Patients With Supine Hypertension
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions: Other: Passive heat stress;   Other: Control (non-heating)
18 Recruiting Magnetic Resonance Spectroscopy in Autonomic Failure
Conditions: Pure Autonomic Failure;   Multiple System Atrophy
Intervention: Procedure: Magnetic Resonance Spectroscopy Imaging
19 Recruiting Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions: Drug: Losartan;   Drug: Captopril;   Drug: Placebo
20 Recruiting The Role of Endothelin in the Supine Hypertension of Autonomic Failure
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions: Drug: BQ123;   Drug: Bq123;   Drug: Saline

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Indicates status has not been verified in more than two years