The Effects of Single-Pulse Transcranial Magnetic Stimulation on the Autonomic Nervous System in Healthy Adults
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|ClinicalTrials.gov Identifier: NCT02833220|
Recruitment Status : Completed
First Posted : July 14, 2016
Last Update Posted : April 16, 2019
|Condition or disease||Intervention/treatment|
|Healthy||Device: Single-Pulse Transcranial Magnetic Stimulation|
The overall purpose of this study is to investigate the effects of TMS on the ANS. Specifically; the investigator aim to determine if single-pulse TMS of the primary motor cortex in the dominant hemisphere in healthy, young adults will significantly affect 1) heart rate and heart rate variability, 2) blood pressure and 3) baroreflex function.
The first purpose of this study is to measure alterations in sympathetic and parasympathetic activation in response to TMS. To do this, we will measure HRV immediately after single-pulse TMS. The second purpose is to investigate the changes in blood pressure in response to TMS and to determine whether the baroreflex, a critical modulator of blood pressure, is inhibited by TMS.
Aim 1: To determine if single-pulse TMS of the primary motor cortex will significantly alter heart rate variability. We hypothesize that single-pulse TMS of the primary motor cortex will elicit an acute decrease in heart rate and result in improved heart rate variability indicated by a significantly decreased LF power and increased HF power.
Aim 2: To determine if single-pulse TMS of the primary motor cortex will significantly alter blood pressure and baroreflex sensitivity (BRS). We hypothesize that single-pulse TMS of the primary motor cortex will elicit an acute decrease in blood pressure by inhibiting the baroreflex.
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||The Effects of Single-Pulse Transcranial Magnetic Stimulation on the Autonomic Nervous System in Healthy Adults|
|Study Start Date :||January 2017|
|Actual Primary Completion Date :||January 2019|
|Actual Study Completion Date :||January 2019|
Device: Single-Pulse Transcranial Magnetic Stimulation
Single-pulse Transcranial Magnetic Stimulation activates neurons within the cortex of the brain by way of electromagnetic induction. This causes a small, focused electric field to become present in the brain, which activates the neurons.
- Change in Blood Pressure during the intervention as compared to baseline [ Time Frame: Change from baseline ]It is possible that blood pressure is changing when the single-pulse transcranial magnetic stimulation is being delivered.
- Change in Heart Rate Variability from baseline [ Time Frame: Change from baseline ]Heart rate variability is a non-invasive measurement of the activity of the parasympathetic nervous system
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02833220
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Manda L Keller-Ross, PhD||University of Minnesota - Clinical and Translational Science Institute|