Energy Metabolism in Patients With Short Bowel Syndrome
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|ClinicalTrials.gov Identifier: NCT02113228|
Recruitment Status : Completed
First Posted : April 14, 2014
Last Update Posted : December 3, 2014
|Condition or disease|
|Short Bowel Syndrome|
|Study Type :||Observational|
|Actual Enrollment :||22 participants|
|Official Title:||Assessment of Energy Metabolism in Patients With Short Bowel Syndrome Using the Doubly Labeled Water Method|
|Study Start Date :||March 2013|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
Short Bowel Syndrome
Verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method.
Verify the total energy expenditure in patients without short bowel syndrome using the doubly labeled water method.
- Assessment of total energy expenditure using the doubly labeled water method [ Time Frame: 14 days ]After the determination of resting energy expenditure (REE), each volunteer will receive a dose of doubly labeled water (2H2 18O). A basal urine sample is collected before the intake dose and samples taken on days 1, 2, 3, 7, 12, 13, 14, thereafter. Urine samples will be analyzed by mass spectrometry (Hydra System, HIP 20-20, Europa Scientific, Cheshire, UK) in the Mass Spectrometry Laboratory of the Faculty of Medicine of Ribeirão Preto.
- Resting energy expenditure (REE) and body composition measurements by indirect calorimetry and electrical bioimpedance, respectively. [ Time Frame: After 12 hours of overnight fasting ]This study also aims to measure the REE by indirect calorimetry with a Quark (Cosmed, Italy) calorimeter and the body composition by Byodinamics 450 (Biodynamics Corp., United States).
- Physical activity assessment [ Time Frame: 14 days ]An activity monitor (activPAL ®, Glasgow, UK) is used to determine physical activity. By registering the intensity and duration of each category of activities, the system adds the energy estimated to generate a value that reflects the total energy expenditure.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02113228
|Clinical Hospital of Ribeirao Preto|
|Ribeirão Preto, Sao Paulo, Brazil, 14048-900|
|Principal Investigator:||Julio S Marchini, PhD||Ribeirão Preto Medical School. São Paulo University (USP)|