Study of the Long Term Efficacy of Recombinant Hepatitis B Vaccine in Nile Delta of Egypt
More than two billion individuals have serological evidence of hepatitis B virus (HBV) infection worldwide. Of these, 240 million are chronic carriers and approximately 786,000 hepatitis B related deaths occur annually.
Currently available hepatitis B vaccines are extremely safe and have an efficacy of >90 percent against all HBV serotypes and genotypes. Thus, HBV infection can potentially be eradicated through global vaccination. A positive immune response to the vaccine is defined as the development of hepatitis B surface antibody (anti-HBs) at a titer of >10 mIU/mL.
Although anti-HBs titers decrease with time, the duration of protection is long. Protection has been estimated to persist for up to 22 years after the primary vaccination schedule. Protection from clinical disease, despite declining or even undetectable anti-HBs levels, is probably due to the priming of memory cells, which are capable of eliciting an anamnestic response when challenged. This is supported by the rapid increases in anti-HBs titers in previously vaccinated individuals who administered booster injections.
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Study of the Long Term Efficacy of Recombinant Hepatitis B Vaccine in Young Adults 20-22 Years After the Primary Vaccination in Nile Delta of Egypt|
- Number of individuals with protective anti-HBs antibody titers [ Time Frame: 1 year ]Number of individuals having protective anti-HBs antibody titers
|Study Start Date:||June 2016|
|Estimated Study Completion Date:||March 2019|
|Estimated Primary Completion Date:||December 2018 (Final data collection date for primary outcome measure)|
Other: Detection of anti HBs antibody titer
A significant proportion of the vaccinated population loses both the protective levels of anti-HBs and an anamnestic response. Recommendations for booster vaccination have been proposed in a European consensus statement. Countries like the Netherlands, Germany, Spain, France and Belgium recommend a booster dose depending on the post-vaccination anti-HBs titer. In the UK, a single booster dose is recommended five years after primary vaccination.
In Egypt, the routine infant immunization for hepatitis B virus started in 1992, and was given at 2nd, 4th and 6th months of age. In the present study the investigators will investigate the long term efficacy of hepatitis B vaccination in young adults 20 to 22 years after the primary vaccination in Nile Delta of Egypt.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02797782
|Contact: Sherief Abd-Elsalam, Consultantfirstname.lastname@example.org|
|Contact: Sherief Abd-elsalam, lecturer 00201000040794 Sherif_tropical@yahoo.com|
|Principal Investigator:||Asem Elfert, Prof||Hepatology and gastroenterology dept.-Tanta|
|Study Chair:||Reham Elkhouly, Consultant||Division of Gastroenterology and Hepatology- Tanta|
|Study Chair:||Rehab Badawi, Consultant||Hepatology and gastroenterology dept.-Tanta|
|Study Chair:||Walaa Elkhalawany, Consultant||Hepatology and gastroenterology dept.-Tanta|
|Study Chair:||Mona Watany, Consultant||clinical pathology dept.-Tanta|
|Study Chair:||Sherief Abd-Elsalam, Consultant||Hepatology and gastroenterology dept.-Tanta|