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Trial record 2 of 110 for:    depression AND stroke recovery

Acute Aerobic Exercise and Neuroplasticity in Depression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02839837
Recruitment Status : Completed
First Posted : July 21, 2016
Last Update Posted : January 30, 2019
Information provided by (Responsible Party):
Medical University of South Carolina

Brief Summary:
Depression is associated with a disruption in the mechanisms that regulate neuroplasticity. Effective treatment and rehabilitation of depression, and other neurological and neuropsychiatric disorders, relies on neuroplasticity. Thus, identifying therapies that enhance neuroplasticity (neuroplastic adaptation) are vital in the comprehensive treatment of depression. Aerobic exercise training has been demonstrated to have antidepressant properties and single bouts of aerobic exercise may provide short-term improvements in affective states in depression. Furthermore, acute aerobic exercise may enhance the response to known neuroplasticity-inducing paradigms. However, it is unclear if aerobic exercise can influence neuroplasticity in depression and the neurobiological mechanisms underlying acute neuroplastic changes are not well understood in depressed and healthy cohorts. Thus, the purpose of this project is to examine the acute effects of aerobic exercise on neuroplastic, neurobiological, and mood indices of depression.

Condition or disease Intervention/treatment Phase
Depression Depressive Disorder Behavioral: Aerobic Exercise Device: Paired Associative Stimulation Not Applicable

Detailed Description:

The investigators will determine the effects of exercising at two different intensities (compared to a control non-exercise condition) on neuroplastic potential in depressed and non-depressed subjects. To accomplish this aim, the investigators will have subjects ride a cycle ergometer at intensities set to elicit 35% (low) and 70% (high) of heart rate reserve (((220 - age) - resting heart rate) x 35% or 70%) + resting heart rate). Prior to, and immediately after exercise participants will have their neuroplastic potential tested via transcranial magnetic stimulation (TMS), blood specimens sampled, and mood changes assessed (methods detailed below). These assessments will occur at these time points and then every 15 minutes for 1 hour after exercise.

Neuroplastic potential will be assessed using TMS. TMS-induced motor evoked potentials (MEP's) will be recorded from the abductor pollicis brevis as a way to measure changes in the excitability of the corticospinal tract in response to exercise and paired associative stimulation. Serum brain-derived neurotrophic factor (BDNF) and cortisol levels will be obtained through blood specimen samples in order to examine the potential exercise-induced changes in known stress- and neuroplasticity-related biomarkers. Mood and affect will be surveyed using the Activation-Deactivation Checklist (AD ACL), feeling scale (FS), and felt arousal scale (FAS). These measures will permit the assessment of exercise-induced changes in mood and affect.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 38 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Other
Official Title: The Benefits of Acute Aerobic Exercise on Neuroplastic Potential in Depression
Actual Study Start Date : May 2016
Actual Primary Completion Date : December 2018
Actual Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Depressed and non-depressed controls
All participants will participate in three different conditions: Low intensity aerobic exercise and paired associative stimulation, high intensity aerobic exercise and paired associative stimulation, no exercise control and paired associative stimulation. The order of conditions will be randomized.
Behavioral: Aerobic Exercise
Aerobic exercise will be performed on a stationary cycle ergometer for 15 minutes at an intensity of 35% heart rate reserve or 70% heart rate reserve. During the control condition the participant will remain seated on the stationary cycle for 15 minutes and will not perform exercise.

Device: Paired Associative Stimulation
After aerobic exercise participants will receive a paired associative stimulation (PAS) paradigm. PAS consists of paired brain and peripheral nerve stimuli. Participants will receive 200 paired stimuli. Peripheral nerve stimulation will be delivered to the median nerve at the level of the wrist via electrical stimulation at 300% perceptual threshold. Brain stimulation will be delivered via transcranial magnetic stimulation (TMS) over the hand knob of the motor cortex at an intensity that elicits a 1mV response in the contralateral abductor pollicis brevis muscle. During each paired stimulation, peripheral nerve stimulation will precede the TMS stimulation by 25ms.

Primary Outcome Measures :
  1. Change in peak to peak MEP amplitude (mV) [ Time Frame: From baseline to one hour post-PAS ]

Secondary Outcome Measures :
  1. Change in serum BDNF (ng/ml) [ Time Frame: From baseline to one hour post-exercise ]
  2. Change in serum cortisol (ng/ml) [ Time Frame: From baseline to one hour post-exercise ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

For all:

  1. age 18-50 year old.
  2. ability to provide informed consent.

Further inclusion criteria for participants with depression:

  1. meets criteria for unipolar depression assessed using the Mini-international Neuropsychiatric Interview (MINI)
  2. a Montgomery Asberg Depression Rating Scale (MADRS) score of 20 or greater
  3. current depressive episode began no longer than 3 years earlier
  4. psychoactive drug free or have maintained a stable dose of up to one antidepressant medication for four weeks prior to study participation

Further inclusion criteria for control participants:

  1. does not meet criteria for unipolar depression assessed using the MINI
  2. a MADRS score of 6 or less
  3. no history or previous diagnosis of depression

Exclusion Criteria (for all participants):

  • primary diagnosis of another Axis 1 disorder
  • secondary diagnosis of a psychotic disorder, cognitive disorder, substance-related disorder, or obsessive compulsive disorder
  • illicit drug use or alcohol abuse
  • current smoker
  • history of seizures
  • other diagnosed neurological or musculoskeletal disorder/injury, uncontrolled cardiovascular or metabolic disease
  • resting blood pressure > 200mmHg systolic or 100mmHg diastolic
  • electronic or metal implants
  • current participation in a structured exercise program
  • pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02839837

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United States, South Carolina
Stroke Recovery Research Center
Charleston, South Carolina, United States, 29425
Sponsors and Collaborators
Medical University of South Carolina
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Principal Investigator: Chris Gregory, P.T., Ph.D. Medical University of South Carolina

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Responsible Party: Medical University of South Carolina Identifier: NCT02839837     History of Changes
Other Study ID Numbers: Pro#00050872
First Posted: July 21, 2016    Key Record Dates
Last Update Posted: January 30, 2019
Last Verified: January 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Medical University of South Carolina:
Depressive Disorder
Non-invasive brain stimulation
Healthy Control
Additional relevant MeSH terms:
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Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders