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Trial record 22 of 540 for:    decongestants

Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

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ClinicalTrials.gov Identifier: NCT02201121
Recruitment Status : Completed
First Posted : July 25, 2014
Last Update Posted : July 25, 2014
Sponsor:
Information provided by (Responsible Party):
Ran Kong, Chinese PLA General Hospital

Brief Summary:
Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

Condition or disease Intervention/treatment Phase
Circulation Drug Dose Calculated SAP Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation Not Applicable

Detailed Description:
Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 94 participants
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Official Title: Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation
Study Start Date : March 2014
Actual Primary Completion Date : June 2014
Actual Study Completion Date : June 2014


Arm Intervention/treatment
Experimental: phenylephrine group, dopamine group, ephedrine group

phenylephrine group: use the phenylephrine to increase the SAP from low to high level.

dopamine group: use the dopamine to increase the SAP from low to high level. ephedrine group:use the ephedrine to increase the SAP from low to high level.

Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation
This research mainly study the effect of clinical commonly used vasoconstrictor drugs on blood pressure of pressure




Primary Outcome Measures :
  1. invasive arterial blood pressure as a Measure of Safety [ Time Frame: DAY 1 ]
    if instability of circulation, stop the clinical trial



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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Their American Society of Anesthesiologists (ASA) physical status was 1 or 2
  • Body mass index (BMI) ranged from 18 to 26
  • None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance
  • All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection

Exclusion Criteria:

  • Persistent arrhythmias
  • Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

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Responsible Party: Ran Kong, Department of Anesthesiology, People's Liberation Army General Hospital, Beijing, China, Chinese PLA General Hospital
ClinicalTrials.gov Identifier: NCT02201121     History of Changes
Other Study ID Numbers: plaghran001
First Posted: July 25, 2014    Key Record Dates
Last Update Posted: July 25, 2014
Last Verified: October 2013

Additional relevant MeSH terms:
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Ephedrine
Nasal Decongestants
Dopamine
Phenylephrine
Oxymetazoline
Pseudoephedrine
Cardiotonic Agents
Sympathomimetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents
Mydriatics
Vasoconstrictor Agents
Respiratory System Agents
Adrenergic alpha-1 Receptor Agonists
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Central Nervous System Stimulants
Bronchodilator Agents
Anti-Asthmatic Agents