Young-Onset Microsatellite-Stable Colorectal Cancer
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Young-Onset Microsatellite-Stable Colorectal Cancer|
- Genomes of Participants Diagnosed with Young-Onset Microsatellite Stable (MSS) Colorectal Cancers (CRCs) vs. Later Onset Microsatellite Stable (MSS) Colorectal Cancers (CRCs) [ Time Frame: 5 years ]Comparisons between the young and the older cohorts performed.
- Polymorphism Variants and/or New Mutations of Participants Diagnosed with Young-Onset Microsatellite Stable (MSS) Colorectal Cancers (CRCs) vs. Later Onset Microsatellite Stable (MSS) Colorectal Cancers (CRCs) [ Time Frame: 5 years ]Test for differences between the young-onset vs. later-onset cohorts for each polymorphism variant or mutation genotype.
Biospecimen Retention: Samples With DNA
|Study Start Date:||June 2012|
|Estimated Primary Completion Date:||June 2022 (Final data collection date for primary outcome measure)|
Questionnaires completed at registration in study or at baseline, and once a year for 5 years. Blood (about 2 tablespoons) collected 1 time.
Participants complete questionnaires about work, family history, medical history, and health habits. Questions are about quality of life, well-being, concerns they may have, as well as the types of health care and follow-up care they are receiving.
Other Name: SurveysProcedure: Blood Draw
About 2 tablespoons blood collected 1 time.
If participant agrees to take part in this study, they will fill out some questionnaires about their work, family history, medical history, and health habits. It should take about 10-15 minutes to complete the questionnaires.
Participant will complete another questionnaire about their experience as a cancer survivor. These questions will be about participant's quality of life, well-being, concerns they may have, as well as the types of health care and follow-up care they are receiving. It should take about 20-25 minutes to complete this questionnaire.
All of the questionnaires will either be given to participant by the research staff at one of their MD Anderson visits or they will be mailed to participant's home with a postage-paid return envelope to mail them back to the study staff.
Blood or Saliva Collection:
Blood (about 2 tablespoons) will be collected 1 time.
If participant is unwilling or unable to give a blood sample, a saliva sample will be collected instead. While participant is at MD Anderson, a saliva collection kit will be given to them.
Length of Study:
If participant is an active patient who has undergone treatment at MD Anderson Cancer Center within the past year, they will receive additional questionnaires 6 and 12 months after they have completed treatment, and then every year for up to 5 years.
If participant is a patient who has completed treatment over 1 year ago, or are a patient, they will also complete a questionnaire at least once every year for up to 5 years.
This is an investigational study.
Up to 1,000 patients and family members will take part in this study. All will be enrolled at MD Anderson.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02863107
|Contact: Yi-Qian N. You, MD||713-792-6940|
|United States, Texas|
|University of Texas MD Anderson Cancer Center||Recruiting|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Yi-Qian N. You, MD||M.D. Anderson Cancer Center|