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Trial record 20 of 593 for:    bilirubin AND liver function

Monitoring Living Donor Liver Functions by Thromboelastometry (TGF)

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ClinicalTrials.gov Identifier: NCT02336191
Recruitment Status : Completed
First Posted : January 12, 2015
Last Update Posted : March 28, 2017
Sponsor:
Information provided by (Responsible Party):
Amr M. Yassen, Mansoura University

Brief Summary:
A prospective Observational study including 50 living donor liver transplant recipients to monitor the graft functions through thromboelastometry

Condition or disease Intervention/treatment
THROMBELASTOGRAPHY and Liver Graft Functions Procedure: living donor liver transplantation

Detailed Description:

This is a prospective observational study Includes 50 living donor liver transplant recipients performed in gastroenterology surgical center - Mansoura University liver transplantation program.

Study period: from June 2014 to May 2015 The early post-operative graft functions will be correlated with concomitant monitored thromboelastometric (TEM) parameters derived from a ROTEM Delt device

TEM Samples will be collected at the following times:

Pre-transplant 10 minutes post portal declamping at ICU admission Morning of Days from 1 to 7 Laboratory data relevant to graft functional status will be collected at the same times.


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Study Type : Observational
Actual Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Monitoring Post-transplant Living Donor Liver Functions by Thromboelastometry. A Prospective Observational Study.
Study Start Date : June 2014
Actual Primary Completion Date : April 2015
Actual Study Completion Date : August 2015

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
LDLT Recipients
Patients subjected to living donor liver transplantation
Procedure: living donor liver transplantation
living donor liver transplantation




Primary Outcome Measures :
  1. r (correlation coefficient) between clot firmness time at 20 minutes, clotting time and INR [ Time Frame: 20 minutes after starting the TEG test ]
    Both blood sample for INR and other lab test and the sample for TEG will be simultaneously drawn from the arterial line for reading of days 0,1 and 2 then from the CVP for the rest of the study readings


Secondary Outcome Measures :
  1. r (correlation coefficient) between clotting time , clot firmness time at 20 minutes and serum bilirubin [ Time Frame: 20 minutes after the start of the TEG test ]
  2. r (correlation coefficient) between clotting time , clot firmness time at 20 minutes and serum SGPT [ Time Frame: 20 minutes after the start of the TEG test ]


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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Living donor liver transplant recipients operated upon in mansoura university liver transplantion project
Criteria

Inclusion Criteria:

  • Living donor liver transplant recipients successively performed in the liver transplantation program - Mansoura university

Exclusion Criteria:

  • Non

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02336191


Locations
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Egypt
Gastroenerology Surgical Center - Liver transplantation program
Mansoura, Dakahlia, Egypt, 35516
Sponsors and Collaborators
Mansoura University
Investigators
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Principal Investigator: amr M Yassen, MD MAnsoura Faculty of Medicine

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Responsible Party: Amr M. Yassen, Professor of Anesthesia and Intensive Care, Mansoura University
ClinicalTrials.gov Identifier: NCT02336191     History of Changes
Other Study ID Numbers: MansouraU_LDLT_TEG
First Posted: January 12, 2015    Key Record Dates
Last Update Posted: March 28, 2017
Last Verified: August 2015
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Amr M. Yassen, Mansoura University:
living donor liver transplantation
graft function
thromboelastometry

Additional relevant MeSH terms:
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Liver Extracts
Hematinics